June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Parallel Variable Interscan Time Analysis (VISTA) OCTA and en Face Doppler OCT of Optic Disc and Peripapillary Vasculature
Author Affiliations & Notes
  • ByungKun Lee
    Department of Electrical Engineering and Computer Science/Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Eric M. Moult
    Department of Electrical Engineering and Computer Science/Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Stefan B. Ploner
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Bavaria, Germany
  • Yasin alibhai
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Carl B Rebhun
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Carlos Moreira
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Lennart Husvogt
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Bavaria, Germany
  • Andreas K Maier
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Bavaria, Germany
  • Gadi Wollstein
    Department of Ophthalmology, New York University, New York, New York, United States
  • Joel S Schuman
    Department of Ophthalmology, New York University, New York, New York, United States
  • Nadia Waheed
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • Jay S Duker
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States
  • James G Fujimoto
    Department of Electrical Engineering and Computer Science/Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   ByungKun Lee, None; Eric Moult, None; Stefan Ploner, None; Yasin alibhai, None; Carl Rebhun, None; Carlos Moreira, None; Lennart Husvogt, None; Andreas Maier, None; Gadi Wollstein, None; Joel Schuman, Carl Zeiss Meditec (P); Nadia Waheed, Carl Zeiss Meditec (R), Genentech (C), Janssen (C), MVRF (F), Nidek (R), Ocudyne (C), Optovue (R), Regeneron (C); Jay Duker, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Optovue (F), Optovue (C), Topcon Medical Systems (F), Topcon Medical Systems (C); James Fujimoto, Optovue (I), Optovue (P)
  • Footnotes
    Support  National Institutes of Health: 5-R01-EY011289-28, 5-R01-EY013178-17; Air Force Office of Scientific Research: FA9550-15-1-0473, FA9550-10-1-0551
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2008. doi:
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    • Get Citation

      ByungKun Lee, Eric M. Moult, Stefan B. Ploner, Yasin alibhai, Carl B Rebhun, Carlos Moreira, Lennart Husvogt, Andreas K Maier, Gadi Wollstein, Joel S Schuman, Nadia Waheed, Jay S Duker, James G Fujimoto; Parallel Variable Interscan Time Analysis (VISTA) OCTA and en Face Doppler OCT of Optic Disc and Peripapillary Vasculature. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2008.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Variable interscan time analysis (VISTA) using high-speed optical coherence tomography (OCT) has improved quantitative interpretation of OCT angiography (OCTA). En face Doppler OCT allows direct quantitative measurement of total retinal blood flow (TRBF). Using VISTA-OCTA and en face Doppler OCT images of the optic disc, we aim to investigate the relationship between radial peripapillary capillary perfusion, optic disc perfusion, and TRBF.

Methods : OCTA and Doppler scans were acquired from eyes with age-related macular degeneration, glaucoma, diabetic retinopathy, and control subjects using a 1050-nm swept-source OCT prototype at a 400 kHz axial scan rate. VISTA-OCTA was performed by acquiring 5 repeated B-scans at each position and calculating the ratio of the OCTA signals in the OCTA images with 1.5 ms and 3 ms interscan times. OCTA volumes were flattened with respect to the vitreoretinal interface and a 190-µm depth slab was projected for visualization of the peripapillary radial capillary plexus. En face Doppler OCT volumes were acquired at a 7.1 volumes/sec scan rate to resolve blood flow pulsatility.

Results : VISTA-OCTA images provided information on the blood flow speed in the large retinal vessels and peripapillary radial capillary plexus. En face Doppler OCT resolved the pulsatility of arterial TRBF and yielded accurate measurement of mean TRBF.

Conclusions : The combination of VISTA-OCTA and en face Doppler OCT may be useful for extracting information on retinal and optic disc blood flow. Different flattening references other than the vitreoretinal interface are desired in order to measure prelaminar and laminar perfusion.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

VISTA and en face Doppler images of (A-E) a glaucoma suspect eye and (F-J) an eye with primary open-angle glaucoma. (A, F) 3-ms interscan time OCTA projection from the vitreoretinal interface to 190-µm depth. (B, G) corresponding VISTA images where blue represents slow flow speeds and red represents fast flow speeds. (C, D, H, I) en face Doppler axial flow velocity image at systole and diastole overlaid on the intensitiy projection. (E, J) plots of pulsatile total retinal blood flow. Scale bars 500 µm.

VISTA and en face Doppler images of (A-E) a glaucoma suspect eye and (F-J) an eye with primary open-angle glaucoma. (A, F) 3-ms interscan time OCTA projection from the vitreoretinal interface to 190-µm depth. (B, G) corresponding VISTA images where blue represents slow flow speeds and red represents fast flow speeds. (C, D, H, I) en face Doppler axial flow velocity image at systole and diastole overlaid on the intensitiy projection. (E, J) plots of pulsatile total retinal blood flow. Scale bars 500 µm.

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