June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Anterior Segment OCT and Specular Microscopy Study in Pediatric Patients: Normal Versus Glaucomatous Eyes
Author Affiliations & Notes
  • Walid Abdallah
    Ophthalmology, Children Hospital of Los Angeles, Los Angeles, California, United States
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Brandon James Wong
    Ophthalmology, Children Hospital of Los Angeles, Los Angeles, California, United States
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Moon Kim
    Allergan, Inc, Irvine, California, United States
  • Dilshad Contractor
    Ophthalmology, Children Hospital of Los Angeles, Los Angeles, California, United States
  • Michelle Chen
    Allergan, Inc, Irvine, California, United States
  • Susan S Lee
    Allergan, Inc, Irvine, California, United States
  • Bibiana Jin Reiser
    Ophthalmology, Children Hospital of Los Angeles, Los Angeles, California, United States
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Walid Abdallah, None; Brandon Wong, None; Moon Kim, Allergan, Inc (C); Dilshad Contractor, Allergan, Inc (F); Michelle Chen, Allergan, Inc (E); Susan Lee, Allergan, Inc (E); Bibiana Reiser, Allergan, Inc (F)
  • Footnotes
    Support  Research grant by Allergan
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2082. doi:
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      Walid Abdallah, Brandon James Wong, Moon Kim, Dilshad Contractor, Michelle Chen, Susan S Lee, Bibiana Jin Reiser; Anterior Segment OCT and Specular Microscopy Study in Pediatric Patients: Normal Versus Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2082.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Anterior segment anatomy evaluation in children is challenging and has been restricted to high-frequency ultrasound, that requires immersion technique. Anterior segment optical coherence tomography (AS-OCT) and specular microscopy are important noninvasive imaging tools, however their role in ocular pediatric diseases has not been well reported. In this study, AS-OCT and specular microscopy were used to evaluate and compare the iridocorneal angles and corneal parameters in normal versus glaucomatous eyes in a pediatric population

Methods : AS-OCT of the temporal iridocorneal angle and specular microscopy were performed on a total of 90 pediatric subjects (70 glaucomatous eyes and 20 normal eyes) from the Children Hospital of Los Angeles using a noncontact technique. AS-OCT images were graded for the ability to visualize Schwalbe’s line (SL), the superior iris surface, and the angle recess. Image J software (1.49v) was used to measure the angle opening distance at SL (SL-AOD) and trabecular-iris-space-area 500 µm posteriorly from SL (SL-TISA) in gradable images. Specular microscopy images were manually analyzed using the center method to determine the endothelial cell density, hexagonality, and coefficient of variation. Student t-test was used to calculate the p-value from the means (statistical significance if <0.05)

Results : OCT and specular microscopy imaging of the anterior segment in the study patients was well tolerated . The mean temporal SL-AOD in the normal eyes is 0.76 +/- 0.22 mm compared with 0.81 +/- 0.26 mm in glaucomatous eyes, with no statistically significant difference between the 2 study groups (P- value: 0.8). The mean temporal SL-TISA in normal eyes is 0.30+/- 0.17 mm2 compared with 0.28 +/- 0.12 mm2 in glaucomatous eyes with no statistically significant difference between the 2 groups (P- value: 0.92).
Data obtained from further analysis of the glaucoma subtypes and specular microscopy are summarized in table-1 & 2

Conclusions : In the present study, there does not appear to be a clinically significant difference in iridocorneal angle biometrics between normal and glaucomatous eyes, however, the endothelial cell density is observed to be lower in glaucomatous eyes. Noncontact AS-OCT and specular microscopy demonstrated to be effective techniques to evaluate the anterior segment providing anatomic details and are useful to clarify diagnoses in the pediatric population.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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