June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The Effect of Ologen ® Collagen Matrix (OCM) in Prevention of Intraocular Pressure spikes after Ahmed Glaucoma Valve Surgery (AGV-FP7): Intermediate results of a 2-Year Follow-up
Author Affiliations & Notes
  • Meliza Unson
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Arkadiy Yadgarov
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Robert Ritch
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Tak Yee Tania Tai
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Reena Garg
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Noga Harizman
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Meliza Unson, None; Arkadiy Yadgarov, None; Robert Ritch, None; Tak Tai, None; Reena Garg, None; Noga Harizman, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2114. doi:
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      Meliza Unson, Arkadiy Yadgarov, Robert Ritch, Tak Yee Tania Tai, Reena Garg, Noga Harizman; The Effect of Ologen ® Collagen Matrix (OCM) in Prevention of Intraocular Pressure spikes after Ahmed Glaucoma Valve Surgery (AGV-FP7): Intermediate results of a 2-Year Follow-up. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2114.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : OCM has been shown to reduce and modulate scarring of the conjunctiva. We propose that guided wound healing will allow a thinner wall around the plate to prevent early post-operative intraocular pressure (IOP) spike. The purpose of this study is to evaluate effectiveness of OCM on the prevention of the post-operative hypertensive phase and on long-term IOP control.

Methods : A prospective, randomized, controlled study was done on eyes with refractory glaucoma requiring an AGV-FP7. Eyes with IOP > 20 mmHg on maximum tolerated glaucoma medications were included. In study eyes, a round 12 mm x 1mm OCM segment was placed flush over the AGV-FP7 plate immediately before conjunctival closure. Student’s t-test was used for statistical analysis.

Results : 18 patients enrolled, 11 were randomized to receive OCM. Mean preoperative IOP was 31.4±9.8 mmHg and 39.1±9.8 mmHg in the study and control group (p=0.12). At post-operative months 1, 2, and 3, the IOP was lower in the study eyes compared to control (p <0.05 at months 1 and 2; p = 0.06 at month 3). At last follow up, there was a statistically significant lowering of post-operative IOP (p<0.05) but there was no significant difference in IOP or medications between groups (16.4±7.8 mmHg and 18.5±6.3 mmHg for control and study eyes, p=0.53).
Two cases in the OCM group (20%) and one case in the control (17%) did not achieve IOP < 21 mmHg.
No surgical revisions or late complications were noted.

Conclusions : Intraoperative implantation of OCM over an AGV-FP7 may prevent a post-operative hypertensive phase. Intermediate data show no long term difference in IOP control between OCM augmented AGV surgery and AGV surgery alone.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure 1. Mean IOP post-operatively after AGV FP7 implantation in control and study eyes. Asterisk denotes statistically significant difference (p <0.05).

Figure 1. Mean IOP post-operatively after AGV FP7 implantation in control and study eyes. Asterisk denotes statistically significant difference (p <0.05).

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