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MARYO KOHEN, Faruk Orge, GUSTAVO GUZMAN, MUKERREM CAKMAK; BIMODAL AMPHIPHILIC CONETWORKS AS THERAPEUTIC CONTACT LENSES FOR THE CONTROL DELIVERY OF TOPICAL DRUGS. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3062.
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© ARVO (1962-2015); The Authors (2016-present)
Therapeutic Contact lenses are thought to be the optimal replacement for eye drops in the delivery of topically applied drug solutions, as they would be able to provide better drug bioavailability and controlled delivery. Bimodal Amphiphilic conetworks (B-APCN) have characteristic such as high oxygen permeation and ability to be loaded with drugs which makes them exceptional materials to be used as therapeutic contact lenses. Using an experimental model of rats, we tested the hypothesis that B-APCN can be molded into contact lenses, and that a drug loaded onto the lens is released over 24 hours.
B-APCN contact lenses dimensions were base curve 3.1 mm, diameter 6.0 mm, and thickness 80 μm. They were were loaded with 0.545 mg/ml moxifloxacin hydrochloride (MH) by immersing them into a solution of same concentration of MH for 12 hours. 4 rats recieved MH loaded contact lenses on their right eyes. After 24 hours 20 microliters of aqueous humor (AH) were withdrawn using Hamilton syringes (Hamilton Company NV, USA) from both right and left eyes. Left eyes' AH were control. MH concentrations were determined using high performance liquid chromatography (HPLC).
B-APCN contact lenses showed good fit and were able to stay on the cornea at the prone position. The mean concentration of MH in AH on the right eyes of the animals were 1239.7 ng/ml which was significantly higher than the mean left eye concentration of MH which was 0.205 ng/ml (p=0.005).
Our results are consistent with our hypothesis that B-APCN material can be molded as contact lenses which can release the loaded drug over time. However, to determine if B-APCN materails can be used as therapeautic contact lenses further testing is needed on the effects of B-APCN on corneal homeostasis.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Image depicting a B-APCN contact lens and its placement on rat's eye
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