June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Comparing Area Measurements of Choroidal Neovascularization Obtained using Different Swept Source OCT Angiographic Scan Patterns in Neovascular Age-Related Macular Degeneration
Author Affiliations & Notes
  • Fang Zheng
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Qinqin Zhang
    University of Washington, Seattle, Washington, United States
  • Andrew R Miller
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Joao Rafael Dias
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Elie Motulsky
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Guanghui Liu
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Zhongdi Chu
    University of Washington, Seattle, Washington, United States
  • Chieh-Li Chen
    University of Washington, Seattle, Washington, United States
  • Sophie Kubach
    Carl Zeiss Meditec, Dublin, California, United States
  • Luis De Sisternes
    Carl Zeiss Meditec, Dublin, California, United States
  • William J Feuer
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Giovanni Gregori
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Mary K Durbin
    Carl Zeiss Meditec, Dublin, California, United States
  • Ruikang K Wang
    University of Washington, Seattle, Washington, United States
  • Philip J Rosenfeld
    University of Miami--Bascom Palmer, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Fang Zheng, None; Qinqin Zhang, None; Andrew Miller, None; Joao Dias, None; Elie Motulsky, None; Guanghui Liu, None; Zhongdi Chu, None; Chieh-Li Chen, None; Sophie Kubach, Carl Zeiss Meditec (E); Luis De Sisternes, Carl Zeiss Meditec (E); William Feuer, None; Giovanni Gregori, Carl Zeiss Meditec (F), Carl Zeiss Meditec (P); Mary Durbin, Carl Zeiss Meditec (E); Ruikang Wang, Carl Zeiss Meditec (P), Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (R); Philip Rosenfeld, Carl Zeiss Meditec (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 50. doi:
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      Fang Zheng, Qinqin Zhang, Andrew R Miller, Joao Rafael Dias, Elie Motulsky, Guanghui Liu, Zhongdi Chu, Chieh-Li Chen, Sophie Kubach, Luis De Sisternes, William J Feuer, Giovanni Gregori, Mary K Durbin, Ruikang K Wang, Philip J Rosenfeld; Comparing Area Measurements of Choroidal Neovascularization Obtained using Different Swept Source OCT Angiographic Scan Patterns in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):50.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the sizes of choroidal neovascularization (CNV) imaged using different scan patterns from the same swept source optical coherence tomography angiography (SS-OCTA) instrument.

Methods : Patients diagnosed with neovascular age-related macular degeneration (AMD) were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 900, Carl Zeiss Meditec, Dublin, CA). The scanning protocols used to image CNV included the 3mm × 3mm and 6mm × 6mm field of view (FOV). The 3mm × 3mm FOV consisted of 300 A-scans per B-scan (repeated four times at each of the 300 B-scan positions), resulting in each A-scan and each B-scan being separated by 10 microns. The 6mm × 6mm FOV consisted of 500 A-scans per B-scan repeated twice at each of the 500 B-scan locations, resulting in a spacing of 12 microns between each adjacent A-scan and B-scan. Neovascular lesions were excluded if they were not fully contained within the 3mm × 3mm FOV. The en face slab used to detect the CNV extended from the outer retina to the choriocapillaris (ORCC slab), and projection artifacts were removed using a proprietary algorithm on each of the scan patterns. A validated automated algorithm was used to measure the area of the CNV.

Results : Thirty-five eyes of 31 patients were enrolled in this comparison study. Seventeen eyes were chosen randomly and have been analyzed thus far. The mean lesion areas were 1.09mm2 (SD=0.74; range: 0.13-2.59) and 1.13 mm2 (SD=0.76; range: 0.17-2.70) for the 3mm x 3mm and 6mm x 6mm FOVs respectively (p=0.34). Differences between area measurements using the two FOVs were not correlated with the lesion size (r=0.15, p=0.56).

Conclusions : The area measurements of CNV were comparable when comparing 3mm x 3mm and 6mm x 6mm SS-OCTA FOVs. Since it might be necessary to increase the SS-OCTA scan area as CNV grows to adequately quantitate the size of the CNV and determine when retreatment might be necessary, it is reassuring to know that different FOVs from the same instrument provide comparable area measurements for the CNV.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

An example of CNV bigger than 2.5mm2. Top: ORCC slab with projection artifacts removed. Bottom: ORCC slab with the outlines of the CNV.

An example of CNV bigger than 2.5mm2. Top: ORCC slab with projection artifacts removed. Bottom: ORCC slab with the outlines of the CNV.

 

An example of CNV smaller than 0.5mm2. Top: ORCC slab with projection artifacts removed. Bottom: ORCC slab with the outlines of the CNV.

An example of CNV smaller than 0.5mm2. Top: ORCC slab with projection artifacts removed. Bottom: ORCC slab with the outlines of the CNV.

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