June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
A comparison of spectral domain optical coherence tomography (sdOCT) circumpapillary and macular measures of progression in patients with severe glaucoma
Author Affiliations & Notes
  • Abinaya Thenappan
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Kevin K Ma
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Ashley Sun
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Ravivarn Jarukasetphon
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • C Gustavo De Moraes
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Robert Ritch
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Donald Hood
    Columbia University College of Physicians and Surgeons, Cerritos, California, United States
  • Footnotes
    Commercial Relationships   Abinaya Thenappan, None; Kevin Ma, None; Ashley Sun, None; Ravivarn Jarukasetphon, None; C Gustavo De Moraes, None; Robert Ritch, None; Donald Hood, Heidelberg Engineering (F), Heidelberg Engineering (R), Topcon Inc (F), Topcon Inc (R)
  • Footnotes
    Support  Joseph M. Cohen Glaucoma Fund of NYEE, NEI RO1-EY-02115, NEI RO1-EY-025253
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 701. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Abinaya Thenappan, Kevin K Ma, Ashley Sun, Ravivarn Jarukasetphon, C Gustavo De Moraes, Robert Ritch, Donald Hood; A comparison of spectral domain optical coherence tomography (sdOCT) circumpapillary and macular measures of progression in patients with severe glaucoma. Invest. Ophthalmol. Vis. Sci. 2017;58(8):701.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The region labeled “less vulnerable” in Fig. 1 is often the last to be affected in patients with severe glaucoma.[1,2] In this study, we ask whether measures of this region are more effective than average circumpapillary retinal nerve fiber layer (cpRNFL) thickness for detecting progression in eyes with severe glaucoma.

Methods : 38 eyes from 36 patients with sdOCT (3D-OCT 2000, Topcon, Inc) disc and macula cube scans across at least two visits were selected from a database of glaucoma patients with 24-2 visual field mean deviations worse than -12dB. For the macula analysis, 43 pairs of intra-visit and 29 pairs of inter-visit macula cube scans (2.6±1.8 yrs on average between visits) of acceptable quality were included. Average ganglion cell complex (GCC) thickness, average retinal ganglion cell plus inner plexiform layer (RGC+) thickness, and percent area of significant thinning (PAST), defined as the percentage of the macula cube scan with cpRNFL thickness less than the 5th percentile of control values, were calculated for the macula (central ±8°), as well as the more and less vulnerable macular regions (Fig. 1). For the circumpapillary analysis, 42 pairs of intra-visit and 24 pairs of inter-visit disc scans (2.7±1.9 years between scans) of acceptable quality were included. Average global cpRNFL and quadrant (superior, temporal, inferior, nasal) thicknesses were calculated. An inter-visit scan difference that exceeded the 95th percentile of the corresponding intra-visit measure was considered to represent progression.

Results : Of the macula measures (Table 1A), the less vulnerable average GCC thickness showed the largest number of progressing eyes (11 of 29). Of the disc measures (Table 1B), the temporal cpRNFL quadrant had the largest number of progressing eyes (6 of 24).

Conclusions : The average GCC thickness of the less vulnerable macula region may be the most effective measure for detecting progression in advanced glaucoma, consistent with the preservation of this region until late in the disease process. As expected, among the cpRNFL metrics, the temporal thickness, which corresponds to the less vulnerable macula region, performed the best. 1. Hood et al., PRER, 2013. 2. Weber et al, Int. Ophthal, 1989

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×