June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal Layer Thickness across 8 Decades of Type 1 Diabetes (DM): Strong correlations with PDR
Author Affiliations & Notes
  • Ward Fickweiler
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Scott R Peterson
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Hillary Keenan
    Medicine, Harvard Medical School, Boston, Massachusetts, United States
    Vascular Cell Biology Section, Joslin Diabetes Center, Boston, Massachusetts, United States
  • George Liang King
    Medicine, Harvard Medical School, Boston, Massachusetts, United States
    Vascular Cell Biology Section, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Lloyd P Aiello
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Jennifer K Sun
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Ward Fickweiler, None; Scott Peterson, None; Hillary Keenan, None; George King, None; Lloyd Aiello, None; Jennifer Sun, Optovue (F)
  • Footnotes
    Support  NIDDK (P30DK036836, UL1 RR025758-03, R24 DK083957-01, DP3 DK094333-01), NEI (1R01EY024702-01, R01 EY026080-01), JDRF (2-SRA-2014-264-M-R , 17-2013-310) Tom Beatson, Jr Foundation, Massachusetts Lions Eye Research Fund
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 83. doi:
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    • Get Citation

      Ward Fickweiler, Scott R Peterson, Hillary Keenan, George Liang King, Lloyd P Aiello, Jennifer K Sun; Retinal Layer Thickness across 8 Decades of Type 1 Diabetes (DM): Strong correlations with PDR. Invest. Ophthalmol. Vis. Sci. 2017;58(8):83.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify factors impacting retinal thickness in type 1 DM patients across a wide range of age, DM duration and DR severity.

Methods : Images were obtained from 50-Year Medalists and shorter DM duration patients at Joslin Diabetes Center without central-involved diabetic macular edema on OCT [central subfield thickness (CST) <305µm females, <320µm males]. Blood pressure (BP), BMI and lipids were recorded. Retinal layers on spectral domain OCT (SDOCT) were segmented and CSTs of Medalists with time domain (TD) OCT converted to TD equivalents and combined with SDOCT data.

Results : For 692 subjects (625 Medalists, 67 non-Medalists), mean±SD age was 64±9 [range: 26-88]yrs, DM duration 52±10 [1-78]yrs, A1c 7.3±1.1 [4.8-15.2]% and 57% female. Overall, 17%, 34%, 9%, 1%, and 39% had no DR; mild, moderate, and severe nonproliferative DR (NPDR); and proliferative DR (PDR), respectively. In bivariate analyses (Table 1), increased CST was associated with greater age (p<0.0001), male gender (p<0.0001), greater age at DM diagnosis (p< 0.0001), lower A1c (p=0.002), lower BMI (p=0.03) and PDR (p=0.0003), but not with DM duration, BP or lipids. With multivariate modelling, CST remained correlated with age (p=0.03), gender (p<0.0001), age at DM diagnosis (p=0.008), BMI (p=0.03) and PDR (p<0.0001). In eyes with no-mild NPDR, age, gender and age at DM diagnosis were associated with CST (all p<0.0001). In eyes with PDR, neither panretinal photocoagulation (N=491) nor macular laser (N=61) was related to CST or central individual layer thickness. There were no significant differences in layer thickness between Medalists and non-Medalists. In the full cohort, after adjusting for age, gender, age at DM diagnosis, and BMI, PDR was associated with increased CST for retinal nerve fiber (p=0.008), ganglion cell (p=0.008), inner nuclear (p=0.0002) and outer plexiform (p=0.01) layers, but decreased CST for outer nuclear (p=0.04), and photoreceptor (p<0.0001) layers.

Conclusions : Across a wide range of age, DM duration and DR severity, factors most closely associated with CST are age, gender, age at DM diagnosis and the presence of PDR. Individual thickness of central retinal layers does not change substantially with increasing DM duration or laser. There is a strong association between PDR and increased CST, although opposing effects on inner versus outer layer thickness are observed.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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