June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal oximetry in multiple sclerosis
Author Affiliations & Notes
  • Olof Birna Olafsdottir
    Ophthalmology, University of Iceland, Reykjavik, Iceland
    Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland
  • Anna Bryndis Einarsdottir
    Neurology, Odense University Hospital, Odense, Denmark
    Neurology, Landspitali University Hospital, Reykjavik, Iceland
  • Sveinn Hakon Hardarson
    Ophthalmology, University of Iceland, Reykjavik, Iceland
  • Einar Stefansson
    Ophthalmology, University of Iceland, Reykjavik, Iceland
    Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland
  • Footnotes
    Commercial Relationships   Olof Olafsdottir, None; Anna Einarsdottir, None; Sveinn Hardarson, Oxymap ehf. (C), Oxymap ehf. (I), Oxymap ehf. (P); Einar Stefansson, Oxymap ehf. (I), Oxymap ehf. (P), Oxymap ehf. (S)
  • Footnotes
    Support  Rannis - The Icelandic Centre for Research PostDoc Grant 152539-052
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3104. doi:
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    • Get Citation

      Olof Birna Olafsdottir, Anna Bryndis Einarsdottir, Sveinn Hakon Hardarson, Einar Stefansson; Retinal oximetry in multiple sclerosis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3104.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optic neuritis is a common presentation of multiple sclerosis (MS). A slow and progressive loss of retinal ganglion cells also happens in eyes that have not had optic neuritis. The purpose of the study was to measure retinal oxygen metabolism in patients with MS.

Methods : Retinal oximetry was performed with a non-invasive spectrophotometric oximeter, Oxymap T1 (Oxymap ehf). Sixteen eyes from eight MS patients with history of optic neuritis in one or both eyes were measured and compared to 20 healthy individuals.

Results : Venular oxygen saturation was increased in MS patients compared to healthy individuals (70.7±3.4% vs. 66.2±4.7; p=0.021, mean±SD). The arteriovenous difference was also lower in MS patients compared to healthy (26.6±3.6% vs. 30.5±4.8%; p=0.049). There was no difference measured in arterioles when patients with MS (97.3±1.7%) and healthy individuals (96.7±2.8%) were compared.

Conclusions : Increased venular oxygen saturation and lower arteriovenous difference in MS indicate decreased oxygen uptake. This may be due to less oxygen demand following atrophy.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Retinal arteriolar (red) and venular (blue) oxygen saturation in patients with MS and healthy individuals. The venular saturation was increased in MS compared to healthy (p=0.021).

Retinal arteriolar (red) and venular (blue) oxygen saturation in patients with MS and healthy individuals. The venular saturation was increased in MS compared to healthy (p=0.021).

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