June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Role of TNF alpha in senile, diabetic and traumatic cataract
Author Affiliations & Notes
  • Eduardo Sebastian Arellano Arias
    Fundacion Hospital Nuestra Se�ora de la Luz, Mexico, Mexico
  • Atzin Robles-Contreras
    Fundacion Hospital Nuestra Se�ora de la Luz, Mexico, Mexico
  • Ana Beatriz Medina-Perez
    Fundacion Hospital Nuestra Se�ora de la Luz, Mexico, Mexico
  • Footnotes
    Commercial Relationships   Eduardo Sebastian Arellano Arias, None; Atzin Robles-Contreras, None; Ana Medina-Perez, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3181. doi:
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      Eduardo Sebastian Arellano Arias, Atzin Robles-Contreras, Ana Beatriz Medina-Perez; Role of TNF alpha in senile, diabetic and traumatic cataract. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3181.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Study Tumor Necrosis Factor alpha (TNF-a) levels in aqueous humor of patients with clinical diagnosis of senile, diabetic and traumatic cataract.

Methods : Samples of aqueous humor of patients with clinical diagnosis of senile, diabetic and traumatic cataract were collected. TNF-a was quantified by ELISA. Results were analyzed with student’s t test.

Results : Average concentration of TNF alpha was 180.239 ± 97.80pg/ml in senile cataracts, 185.656 ± 116.431pg/ml in diabetic cataracts and 254.935 ± 220.471pg/ml in traumatic cataracts. There was no statistical difference between senile and diabetic cataracts (p=0.453), senile and traumatic cataracts (p=0.310), or diabetic and traumatic cataracts (p=0.322).

Conclusions : Due to comparable values of TNF-a in aqueous humor of senile, diabetic and traumatic cataracts, knowing there is an overexpression of Tumor Necrosis Factor receptor (TNFR) in diabetic and traumatic cataracts, we propose an upregulation of TNFR in diabetic and traumatic cataracts. This would justify a predominant inflammatory mechanism in diabetic and traumatic cataract. Thus, we propose that senile cataracts have a different immunophysiopathology from diabetic and traumatic cataract.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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