June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Dynamic changes of iridocorneal angle morphology during accommodation in healthy children
Author Affiliations & Notes
  • Moritz Claudius Daniel
    Department of Paediatric Ophthalmology and Strabismus, NIHR Moorfields Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
    Eye Center, Medical Center, University of Freiburg, Freiburg, Germany
  • Becky MacPhee
    Moorfields Eye Hospital, London, United Kingdom
  • Patricia Ibanez
    Moorfields Eye Hospital, London, United Kingdom
  • Nadia Venturi
    Orthoptics, Moorfields Eye Hospital, London, United Kingdom
  • Adam M Dubis
    BRC at Moorfields Eye Hospital and UCL-Institute of Ophthalmology, London, United Kingdom
  • Maria Theodorou
    Department of Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital, London, United Kingdom
  • Gillian GW Adams
    Moorfields Eye Hospital, London, United Kingdom
  • Maria Papadopoulos
    Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom
  • John Brookes
    Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom
  • Peng Tee Khaw
    Glaucoma Service, Moorfields Eye Hospital, London, United Kingdom
  • Annegret H Dahlmann-Noor
    Department of Paediatric Ophthalmology and Strabismus, NIHR Moorfields Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships   Moritz Daniel, None; Becky MacPhee, None; Patricia Ibanez, None; Nadia Venturi, None; Adam Dubis, None; Maria Theodorou, None; Gillian Adams, None; Maria Papadopoulos, None; John Brookes, None; Peng Khaw, None; Annegret Dahlmann-Noor, None
  • Footnotes
    Support  Wates Foundation and Fight for Sight (1706/07)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3466. doi:
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      Moritz Claudius Daniel, Becky MacPhee, Patricia Ibanez, Nadia Venturi, Adam M Dubis, Maria Theodorou, Gillian GW Adams, Maria Papadopoulos, John Brookes, Peng Tee Khaw, Annegret H Dahlmann-Noor; Dynamic changes of iridocorneal angle morphology during accommodation in healthy children. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3466.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The dynamics of the iridocorneal angle (ICA) during accommodative effort have not previously been explored, though anatomy would indicate that Schlemm’s canal (SC) morphology may be affected by ciliary muscle (CM) contraction. This work aims to describe changes in ICA morphology in children, a population with a naturally large range of accommodation.

Methods : We acquired anterior segment OCT images (Tomey SS-1000 CASIA, Nagoya, Japan) of ICA and CM of the right eye of 50 children age 4 to 16 years with healthy eyes, at 2 levels of accommodation: 2.5D (“relaxed”) and 15D (“intense accommodative effort”). We noted triplicates of semi-automated nasal ICA measurements: angle opening distance at 500/750 μm (AOD-500, -750), trabecular iris space area at 500/750 μm (TISA-500, -750) and trabecular iris angle at 500/750 μm (TIA-500, -750). One observer manually obtained triplicate measurements of SC diameter (SC-D) and cross-sectional area (SC-CSA) and CM width at 1, 2 and 3 mm from scleral spur (CM-1, CM-2, CM-3). Triplicates were summarised as means. Using SPSS24 (IBM, Armonk, USA) we calculated cohort means and standard deviations (SD). Comparisons: 1) all parameters: 2 tailed t-test with cutoff at a) age 10 years and b) spherical equivalent of 0D; 2) SC-D, SC-CSA, CM-1, 2, 3: 2-tailed paired t-test.

Results : Image quality was adequate for analysis in a high proportion (Table 1). SC parameters and CM width were not significantly different in younger versus older or myopic versus emmetropic/hypermetropic children (p>0.05). SC-D and CM-1 significantly increased with intense accommodative effort, whilst CM-3 significantly decreased (Table 1).

Conclusions : This is the first study to demonstrate dynamic changes in SC-D with accommodation in humans.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Table 1. ICA, SC parameters and CM width on standard and high-resolution AS-OCT with relaxed and intense accommodative effort.

Table 1. ICA, SC parameters and CM width on standard and high-resolution AS-OCT with relaxed and intense accommodative effort.

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