June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Agreement between Automated and Manual Corneal Thickness Mapping for Pachymetry, Epithelium, and Stroma from iVue SD-OCT and Avanti SD-OCT
Author Affiliations & Notes
  • Xingwei Wang
    Optovue, Fremont, Colorado, United States
  • Kelly A Soules
    Optovue, Fremont, Colorado, United States
  • Yulia Wolfson
    Optovue, Fremont, Colorado, United States
  • Susan Luh
    Optovue, Fremont, Colorado, United States
  • Yi-Sing Hsiao
    Optovue, Fremont, Colorado, United States
  • Ben K Jang
    Optovue, Fremont, Colorado, United States
  • Qienyuan Zhou
    Optovue, Fremont, Colorado, United States
  • Footnotes
    Commercial Relationships   Xingwei Wang, Optovue (E); Kelly Soules, Optovue (E); Yulia Wolfson, Optovue (E); Susan Luh, Optovue (E); Yi-Sing Hsiao, Optovue (E); Ben Jang, Optovue (E); Qienyuan Zhou, Optovue (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3513. doi:
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    • Get Citation

      Xingwei Wang, Kelly A Soules, Yulia Wolfson, Susan Luh, Yi-Sing Hsiao, Ben K Jang, Qienyuan Zhou; Agreement between Automated and Manual Corneal Thickness Mapping for Pachymetry, Epithelium, and Stroma from iVue SD-OCT and Avanti SD-OCT. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3513.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the accuracy of automatically produced corneal thickness maps from iVue and Avanti SD-OCT corneal B-scans (Optovue, Inc., Fremont, CA) and their agreement with manual B-scan corneal thickness measurements in normal eyes and eyes with corneal pathologies.

Methods : A total of 88 eyes from 88 subjects (17 Normal, 16 contact-lens, 19 dry-eye, 20 post-laser refractive surgery, and 16 keratoconus) were enrolled in IRB approved studies across three study sites. Four eyes’ data were excluded from analysis due to insufficient OCT scan quality: one from iVue and three from Avanti data sets. Manual grading was performed on the 87 qualified iVue and 85 Avanti scans. Corneal pachymetry scans from the same eye were acquired on iVue and Avanti (Fig.1A and 1B) systems. Thickness maps including corneal pachymetry, epithelial, and stroma measurements were automatically generated in the central 6 mm and 9 mm diameter regions of the cornea on iVue and Avanti, accordingly. The accuracy of the software-generated thickness maps computed from the automatic segmented boundaries (Fig. 1C) was assessed by the agreement with averaged manual measurements (Fig. 1D) from three independent human graders for 17 and 25 zonal thickness parameters on iVue and Avanti, respectively (Fig. 2A and 2B).

Results : For all map zones on both systems, the mean of differences between the automatic and manual measurements was less than 0.7 and 1.4 μm for corneal epithelial mapping, less than 1.9 and 5.9 μm for corneal stroma mapping, and less than 2.3 and 4.7 μm for pachymetry mapping on iVue and Avanti systems respectively (Fig. 2, Tables 1 and 2).

Conclusions : This study demonstrated the automatically generated corneal maps by iVue and Avanti are accurate, as shown by good agreement with manual measurements.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure 1. Pachymetry B-scans with (A) iVue SD-OCT (6 mm diameter) and (B) Avanti SD-OCT (9 mm diameter), (C) automatically segmented anterior epithelial, posterior epithelial and endothelial boundaries, and (D) manual thickness measurements.

Figure 1. Pachymetry B-scans with (A) iVue SD-OCT (6 mm diameter) and (B) Avanti SD-OCT (9 mm diameter), (C) automatically segmented anterior epithelial, posterior epithelial and endothelial boundaries, and (D) manual thickness measurements.

 

Figure 2. The differences between manual measurements and software-generated thickness maps for all zones on iVue 6 mm and Avanti 9 mm cornea scans.

Figure 2. The differences between manual measurements and software-generated thickness maps for all zones on iVue 6 mm and Avanti 9 mm cornea scans.

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