June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
A comparison of OCT peripapillary and disc measures among non-arteritic ischemic optic neuropathy (NAION), open-angle glaucoma (OAG), and healthy controls
Author Affiliations & Notes
  • Thet Naing
    Psychology, Columbia University, New York, New York, United States
  • Seung Lee
    Psychology, Columbia University, New York, New York, United States
  • Lynn Shi
    Ophthalmology, Columbia University, New York, New York, United States
    Psychology, Columbia University, New York, New York, United States
  • Jeffrey Odel
    Ophthalmology, Columbia University, New York, New York, United States
  • Robert Ritch
    Ophthalmology, New York Eye & Ear Infirmary , New York, New York, United States
  • Donald Hood
    Psychology, Columbia University, New York, New York, United States
    Ophthalmology, Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Thet Naing, None; Seung Lee, None; Lynn Shi, None; Jeffrey Odel, None; Robert Ritch, None; Donald Hood, Heidelberg Engineering (F), Heidelberg Engineering (R), Topcon, Inc. (F), Topcon, Inc. (R)
  • Footnotes
    Support  NEI RO1-EY-02115
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3850. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Thet Naing, Seung Lee, Lynn Shi, Jeffrey Odel, Robert Ritch, Donald Hood; A comparison of OCT peripapillary and disc measures among non-arteritic ischemic optic neuropathy (NAION), open-angle glaucoma (OAG), and healthy controls. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3850.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To better understand the effects of NAION and OAG on neural and non-neural tissue in and around the disc, we used optical coherence tomography (OCT) and compared various measures including Bruch’s membrane opening-minimum rim width (BMO-MRW), horizontal rim width (BMO-HRW), and peripapillary retinal nerve fiber layer (pRNFL) thickness among patients with NAION and OAG, and healthy controls.

Methods : 10 eyes with NAION (64.9±12.2yrs), 10 eyes with OAG (66.3±14.0yrs), and 10 age-similar healthy control eyes (66.3±14.0yrs) had 12 radial line scans centered on the optic disc acquired using swept-source OCT (DRI-OCT, Topcon). OAG eyes were pairwise selected to match the NAION eyes; each pair matched in age, 24-2 mean deviation (-16.2±2.7 vs. 16.4±3.3, P=0.96), and region of field loss. A region of interest (ROI) was defined as 3 consecutive radial line scans through the portion of the disc with damage. For the ROI in NAION, OAG, and their matched controls, we determined: BMO-HRW, lamina cribrosa thickness (LCT), anterior lamina cribrosa depth (ALD), and minimum pre-laminar tissue thickness (PLT). Additionally, on each radial line scan, we measured the BMO-MRW and pRNFL (at 1.7 mm from disc center) thickness. One-way analysis of variance and the Kruskal–Wallis H test were used to compare among groups, where appropriate. Pairwise comparisons were adjusted for multiple comparisons using the Bonferroni method.

Results : Table 1 summarizes the results. Compared to healthy eyes, NAION eyes had similar LCT [1] and BMO-MRW. Compared to OAG eyes, NAION eyes had similar pRNFL thickness, both of which were thinner than healthy eyes (Fig. 1, top, bars are ±1SE). However, NAION and healthy eyes had thicker MRW (Fig. 1, bottom), HRW, LCT and PLT than OAG eyes. Interestingly, HRW, MRW/pRNFL and HRW/pRNFL were all larger in NAION than in OAG or healthy eyes.

Conclusions : Prelaminar and lamina cribrosa thickness, and MRW/pRNFL and HRW/pRNFL ratios, differ in NAION and OAG eyes. OCT scans of the disc may be used in distinguishing between NAION and glaucoma. 1. Fard et al., IOVS, 2016.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×