June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The Effects of Refractive Error and Related Optic Nerve Head (ONH) Anatomical Parameters on Optical Coherence Tomography (OCT) Retinal Nerve Fiber Layer (RNFL) Deviation Map
Author Affiliations & Notes
  • Neda Baniasadi
    Ophthalmology, Schepens Eye Research Institute, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
    Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts, United States
  • Mengyu Wang
    Ophthalmology, Schepens Eye Research Institute, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
  • Hui Wang
    Ophthalmology, Schepens Eye Research Institute, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
    Institute for Psychology and Behavior, Jilin University of Finance and Economics, Changchun, Jilin, China
  • Qingying Jin
    Jilin University, Changchun, Jilin, China
  • Mufeed Mahd
    Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts, United States
  • Lucy Q Shen
    Ophthalmology, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
  • Louis R Pasquale
    Ophthalmology, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
  • Tobias Elze
    Ophthalmology, Schepens Eye Research Institute, Mass. Eye and Ear, Harvard Medical School , Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Neda Baniasadi, None; Mengyu Wang, None; Hui Wang, None; Qingying Jin, None; Mufeed Mahd, None; Lucy Shen, None; Louis Pasquale, None; Tobias Elze, United States PCT/US2014/052414 (P)
  • Footnotes
    Support  Lions Foundation Grant 2015; Grimshaw-Gudewicz Foundation 2016; Harvard Glaucoma Center of Excellence; Eleanor and Miles Shore Fellowship; China Scholarship Council NO.201408220092
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3991. doi:
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      Neda Baniasadi, Mengyu Wang, Hui Wang, Qingying Jin, Mufeed Mahd, Lucy Q Shen, Louis R Pasquale, Tobias Elze; The Effects of Refractive Error and Related Optic Nerve Head (ONH) Anatomical Parameters on Optical Coherence Tomography (OCT) Retinal Nerve Fiber Layer (RNFL) Deviation Map. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3991.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The impact of spherical equivalent (SE) on RNFL thickness (RNFLT) may be modified by anatomical parameters. Here, we evaluate the effects of SE and related retinal parameters on OCT abnormality color marks on RNFL deviation map, independent of glaucoma severity.

Methods : Reliable pairs of Cirrus OCT circumpapillary RNFLT measurements and Humphrey 24-2 visual fields (VF) of 421 eyes of 421 glaucoma patients were included. Retinal parameters related to SE (ONH nasal/temporal curvatures measured by the slope of the best lines fitted to the inner limiting membrane, angle between major superior and inferior temporal retinal arteries [inter-artery angle, IAA], and ONH tilt [TL]) were identified on OCT fundus images and/or B-scans (Figures 1 and 2). RNFL deviation maps were extracted from the OCT fundus image on the area of 5.4×5.4 mm around the ONH center with a resolution of 40,401 pixels. For each pixel, a logistic regression model was calculated with OCT abnormality marks on RNFL deviation map as regressands and each parameter as a regressor independent of glaucoma severity (shown as “parameter|MD”), and independent of SE and MD (shown as “parameter|SE,MD”). The results are presented on spatial maps of the entire scanning area. Each of the 40,401 pixels for which there is a significant effect of the parameter (p < 0.05 after correction for multiple comparisons) on abnormality marks represents a location where the related factor may confound glaucoma diagnosis independent of SE and/or MD and is shown in blue/red colors.

Results : Quantified by the affected scanning area, we observed the following parameter effects: IAA: 38.8%, ONH nasal curvature: 29.8%, SE: 22.5%, TL: 5.8%, temporal curvature: 0%, independent of MD (Figures 1 and 2). After excluding co-variation effects with SE, considerable proportions of the areas for IAA (35.1%), and ONH nasal curvature (23.4%) still remain affected.

Conclusions : Variations in IAA and ONH nasal curvature can affect OCT abnormality ratings independent of glaucoma severity and SE. These parameters should be considered in addition to SE while introducing new RNFLT norms for OCT machines.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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