June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Stability of the suprachoroidal electrode array during one-month implantation in rabbit eyes
Author Affiliations & Notes
  • Yasuo Terasawa
    Artificial Vision Institute, R&D Div., Nidek Co., Ltd., Gamagori, Aichi, Japan
    Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Hiroyuki Tashiro
    Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Department of Health Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Yukari Nakano
    Artificial Vision Institute, R&D Div., Nidek Co., Ltd., Gamagori, Aichi, Japan
  • Motoki Ozawa
    Nidek Co., Ltd., Gamagori, Aichi, Japan
  • Footnotes
    Commercial Relationships   Yasuo Terasawa, Nidek Co., Ltd. (E); Hiroyuki Tashiro, Nidek Co., Ltd. (F); Yukari Nakano, Nidek Co., Ltd. (E); Motoki Ozawa, Nidek Co., Ltd. (E)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4195. doi:
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    • Get Citation

      Yasuo Terasawa, Hiroyuki Tashiro, Yukari Nakano, Motoki Ozawa; Stability of the suprachoroidal electrode array during one-month implantation in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4195.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We have been developing a retinal prosthesis with suprachoroidal transretinal stimulation (STS). The purpose of this study is to quantify the lateral movement of suprachoroidally implanted electrode array after implantation surgery.

Methods : Eight 2-channel electrode arrays were suprachoroidally implanted to the eyes of rabbits. After 2-week recovery period, electrical stimulation with 0.75µC/phase at 50Hz was applied to the stimulation electrode for 8 hours per day for 4 weeks. Fundus photography was performed immediately after electrode implantation, after 2-weeks recovery period, after 4-weeks electrical stimulation respectively. The electrode position relative to blood vessels around optic nerve head was estimated from the fundus photos.

Results : Five of eight electrode arrays were visible in fundus photos. Electrode movement at the early phase (movement between the day just after implantation and the day after 2-weeks recovery) was 582±265 µm (Mean vs S.E.M), which was significantly larger than that of the later phase (movement between the day after 2-weeks recovery and the day after 4-weeks stimulation, p<0.05 paired t-test). Electrodes had a tendency to move from temporal to nasal both in the early phase and in the later phase.

Conclusions : The measured movement was less than 1 mm and was comparable to previous similar study (Nayagam et al., PLOS ONE, 2014). The smaller movement in the later phase suggested that the electrode array became stabilized possibly due to the encapsulation of fibrous tissue around the electrode array. The tendency of movement from temporal to nasal suggested that one of the driving forces of electrode movement was the residual stress from the lead which was connected to the electrode and was sutured onto the sclera. Minimizing the stiffness of the lead would help stabilizing the electrode array.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Fig.1 Estimation of electrode position. A: fundus photo just after electrode implantation. stimulation electrodes are indicated by yellow arrows. B: Blood vessels and electrode positions estimated by the fundus photos.

Fig.1 Estimation of electrode position. A: fundus photo just after electrode implantation. stimulation electrodes are indicated by yellow arrows. B: Blood vessels and electrode positions estimated by the fundus photos.

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