June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Choroidal thickness (CT) in thyroid associated orbitopathy (TAO)
Author Affiliations & Notes
  • Kam-lung, Kelvin Chong
    Ophthalmology and Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
    Ophthalmology and Visual Science, The Prince of Wales Hospital, Hong Kong, Hong Kong
  • Tiara Iao
    Ophthalmology and Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Frank Lai
    Ophthalmology and Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
    Ophthalmology , Caritas Medical Centre, Hong Kong, Hong Kong
  • Danny Siu Chun Ng
    Ophthalmology and Visual Science, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Joy Leung
    Ophthalmology , Hospital Authority-Hong Kong East Cluster, Hong Kong, Hong Kong
  • Alvin Au
    Ophthalmology , Hospital Authority-Hong Kong East Cluster, Hong Kong, Hong Kong
  • TC Ko
    Ophthalmology , Hospital Authority-Hong Kong East Cluster, Hong Kong, Hong Kong
  • Alvin L Young
    Ophthalmology and Visual Science, The Prince of Wales Hospital, Hong Kong, Hong Kong
  • Footnotes
    Commercial Relationships   Kam-lung, Kelvin Chong, None; Tiara Iao , None; Frank Lai, None; Danny Ng, None; Joy Leung, None; Alvin Au, None; TC Ko, None; Alvin Young, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5156. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Kam-lung, Kelvin Chong, Tiara Iao, Frank Lai, Danny Siu Chun Ng, Joy Leung, Alvin Au, TC Ko, Alvin L Young; Choroidal thickness (CT) in thyroid associated orbitopathy (TAO). Invest. Ophthalmol. Vis. Sci. 2017;58(8):5156.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Subfoveal CT measured by spectral-domain optical coherence tomography (SD-OCT) was recently found to be increased in patients with TAO compared to healthy control and correlated with clinical activity score (CAS) in 2 separate Turkish cohorts. We conducted a prospective observational cross-sectional study to compare different topographic measurements of CT in Chinese patients with TAO and age-matched healthy subjects and to examine if similar correlations were present.

Methods : CT was measured with enhanced-depth imaging (EDI) by SD-OCT at the subfoveal, parafoveal (1 and 2 mm from central fovea) and peripapillary regions at each quadrant in TAO (n=104) and controls (n=52) by a masked, experienced operator. Comprehensive ophthalmic examinations including CAS and Hertel exophthalmolmetry were performed by an experienced oculoplastic surgeon unaware of the CT measurements. Generalized estimating equation models were used to compare the CT between eyes with TAO and control, and to evaluate the association of subfoveal CT with demographic and ocular parameters in TAO patients.

Results : Age, gender ratio, intraocular pressure (IOP), axial length (AL) and best-corrected visual acuities (BCVA) were comparable between TAO patients and healthy subjects (all p>0.5). Comparing TAO with control eyes, the CT was significantly increased at subfoveal (p=0.003) and parafoveal regions at 1mm and 2mm from the central fovea of each quadrant (all p<0.05), except 2mm inferior to the central fovea (p=0.164) and each of the peripapillary region (superior, p= 0.238; nasal, p=0.576, inferior, p=0.565; temporal, p=0.104) after adjusting for age, AL, IOP, spherical equivalent and exophthalmometry readings. In multivariate analyses, thinner subfoveal CT was associated with proptosis (p=0.043), poorer BCVA (p=0.017), older age (p=0.04) and longer AL (p<0.001). Neither IOP (p=0.44) or CAS (p=0.1) was found to be significantly associated with the CT in this TAO cohort.

Conclusions : We confirmed the findings of 2 prior studies on the increase in subfoveal CT of TAO patients compared to control while we reported for the first time, similar increase in parafoveal but not in peripapillary CT. Proptosis and poorer BCVA but not CAS was found to be associated with thinner subfoveal CT in this Chinese TAO cohort.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Typical example of a thyroid-associated orbitopathy patient with asymmetric disease. The more proptotic eye showed a thinner subfoveal choroidal thickness.

Typical example of a thyroid-associated orbitopathy patient with asymmetric disease. The more proptotic eye showed a thinner subfoveal choroidal thickness.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×