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Gaurav M. Chandra, Scott E Brodie; Scotopic dim blue and white flash responses closely correlated in full-field electroretinography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5343.
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© ARVO (1962-2015); The Authors (2016-present)
The full-field electroretinogram (ERG) is a widely utilized tool to assess mass retinal function. While the International Society for Clinical Electrophysiology of Vision (ISCEV) specifies standard flashes as broad-spectrum and visibly white, colored filters or colored light-emitting diodes (LEDs) have been used to enhance the separation of rod and cone responses and may offer certain advantages.1 This retrospective study compares responses to dim blue and white flashes under scotopic conditions.
Data was collected from full-field ERG responses measured in right eyes of 268 subjects in an ERG database at Mount Sinai Hospital in New York, NY, obtained between 2011-2015. Scotopic responses were recorded after dark-adaptation with single flashes of blue light (0.01 cd-s/m2) and white light (0.05 cd-s/m2). B-wave amplitude (mV) and implicit time (milliseconds) were measured and recorded for blue and white flashes, from averaged waveforms. A Pearson correlation coefficient was used to quantify the similarities between the responses.
B-wave amplitudes showed strong correlation between blue and white flashes with a conversion factor of 1.3 and a correlation of R2 = 0.88. B-wave implicit time showed correlation between blue and white flashes with a conversion factor of 0.98 and R2 = 0.41. Results are illustrated in Figures 1 and 2, below.
These results show excellent correlation between B-wave amplitude and strong correlation between B-wave implicit time for blue and white flashes, suggesting that either may be used to record the scotopic rod-isolated ERG component.1ISCEV Standard for full-field clinical electroretinography (2015 update) Daphne L. McCulloch, Michael F. Marmor, Mitchell G. Brigell, Ruth Hamilton Doc Ophthalmol (2015) 130:1–12
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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