June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Flexible Acrylic Keratoprosthesis
Author Affiliations & Notes
  • Charles Yu
    Ophthalmology, University of Illinois Chicago, Chicago, Illinois, United States
  • Ahmed Al-Qahtani
    Ophthalmology, University of Illinois Chicago, Chicago, Illinois, United States
  • Mark Rosenblatt
    Ophthalmology, University of Illinois Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Charles Yu, None; Ahmed Al-Qahtani, None; Mark Rosenblatt, None
  • Footnotes
    Support  Research to Prevent Blindness, NEI K12EY021475, EverSight
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5705. doi:
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    • Get Citation

      Charles Yu, Ahmed Al-Qahtani, Mark Rosenblatt; Flexible Acrylic Keratoprosthesis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5705.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We hypothesize that a keratoprosthesis can be constructed of biocompatible flexible acrylic such as that commonly used in intraocular lenses and can be used to restore the corneal visual axis in a minimally invasive manner without the need for cornea carrier tissue.

Methods : A keratoprosthesis mold was produced using computer aided design software. A mixture of phenylethyl methacrylate, phenylethyl acrylate, hexanediol crosslinking agent, and free radical initiator was poured into the mold and allowed to polymerize overnight at 100C to form a keratoprosthesis. The keratoprosthesis was assessed for toxicity by MTT assay. It was implanted into ex vivo cadaveric eyes. It was then tested in vivo in 5 rabbits.

Results : After polymerization a flexible clear acrylic keratoprosthesis is produced. It showed ability to deform and flex when warm, but remained stiff and in shape at room temperature. The material was not found to be toxic by MTT assay. It could be implanted into a 3 mm corneal trephination. 5 rabbits were able to retain the keratoprosthesis for 1 month.

Conclusions : A full thickness flexible acrylic keratoprosthesis can be produced and implanted into the cornea through a 3 mm trephination without need for carrier cornea tissue.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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