June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Algorithmic Analysis of Vitreous Hyperreflective Foci in OCT Scans of Patients with Uveitis as a Correlate of Inflamation and Visual Acuity
Author Affiliations & Notes
  • Edward Korot
    Beaumont Eye Institute, Royal Oak, Michigan, United States
    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Vaidehi Dedania
    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Thiran Jayasundera
    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Grant Michael Comer
    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, United States
  • David A Antonetti
    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Footnotes
    Commercial Relationships   Edward Korot, None; Vaidehi Dedania, None; Thiran Jayasundera, None; Grant Comer, None; David Antonetti, None
  • Footnotes
    Support  NIH grant EY012021; the Jules and Doris Stein Professorship from Research to Prevent Blindness (Dr Antonetti); and core grants EY007003 (Core Center for Vision Research at the Kellogg Eye Center) and DK020572 (imaging core of the Michigan Diabetes Research and Training Center). The JDRF (formerly Juvenile Diabetes Research Foundation) provided funding and support for data collection and analysis.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1866. doi:
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      Edward Korot, Vaidehi Dedania, Thiran Jayasundera, Grant Michael Comer, David A Antonetti; Algorithmic Analysis of Vitreous Hyperreflective Foci in OCT Scans of Patients with Uveitis as a Correlate of Inflamation and Visual Acuity. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1866.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify vitreous hyperreflective foci (VHRF) from optical coherence tomography (OCT) in patients with uveitis by using an algorithm we previously validated on patients with diabetic retinopathy.

Methods : Retrospective analysis of 97-slice OCT scans from 55 eyes (52 patients) with established uveitis compared to healthy controls.

We used an algorithm which enhanced the vitreous imaging from OCT, performed automated quantification of VHRF, and calculated a VHRF score representing foci per vitreous volume analyzed for each scan (Figure 1). This score was compared between control eyes, and eyes with uveitis.

Results : VHRF scores were significantly greater in the 12 eyes with uveitis (p<.0001), suggesting VHRF is associated with inflammatory disease. Additionally, LogMAR visual acuity correlated positively with VHRF (p=.0031).

Artifacts were present in OCT scans of 6 eyes with uveitis and 1 control, which were excluded from analysis. Grubbs’ test of outliers was performed, and 2 control eyes had VHRF scores that were significant outliers which were also excluded from analysis.

Conclusions : VHRF scores may provide an objective and noninvasive measure of intraocular inflammation. Additional large-scale studies will further define the relationship of VHRF to uveitis and subgroup uveitis grade, as well as help determine the value of VHRF score in initiating therapeutic intervention and monitoring of treatment response.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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