June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Repeatability and reproducibility of retinal hemodynamic parameters by using Doppler OCT
Author Affiliations & Notes
  • Shenghai Huang
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Meixiao Shen
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Dexi Zhu
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Ce Shi
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Fan Lu
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Footnotes
    Commercial Relationships   Shenghai Huang, None; Meixiao Shen, None; Dexi Zhu, None; Ce Shi, None; Fan Lu, None
  • Footnotes
    Support  National Nature Science Foundation of China 81400441; National Nature Science of Zhejiang Province LY14H180007 and LQ17H180004
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3105. doi:
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    • Get Citation

      Shenghai Huang, Meixiao Shen, Dexi Zhu, Ce Shi, Fan Lu; Repeatability and reproducibility of retinal hemodynamic parameters by using Doppler OCT. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3105.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the repeatability and reproducibility of angle-independent hemodynamic parameters in young health subjects by using Doppler optical coherence tomography (OCT).

Methods : A custom built spectral domain OCT was used to image retinal vessels in optic disc area. The phase resolved Doppler OCT was developed to obtain the pulsatility of retinal vessels. Two angle-independent, pulsatility index (PI) and resistance index (RI), were defined based pulsatility of vessels. 7 left eyes of 7 healthy subjects were included. The raster scan was first performed to obtain the morphology of retinal vessels. Then repeated scan at the superior and inferior of the optic disc was performed to get the Doppler images. Three repeated measurements was performed. The first two measurements were collected by examiner 1 for repeatability study and the last measurement was collected by examiner 2 for reproducibility study. The intraclass correlation coefficient (ICC), coefficients of repeatability and reproducibility (COR) and Bland-Altman plot were analyzed to evaluate the reliability.

Results : A total of 28 vessels from 7 left eyes were collected at optic disc area for Doppler imaging. The value of PI was 1.34±0.22. The p-values of T-test for the intra-observer repeatability and inter-observer reproducibility were 0.570 and 0.968. The CORs were 13.97% and13.18%. In Bland-Altman plot, most of the values were in 95% confidence interval. ICCs were 0.922[0.840, 0.963] and 0.923[0.840, 0.963]. The value of RI was 0.89±0.08. The p-values of T-test for the intra-observer repeatability and inter-observer reproducibility were 0.491 and 0.939. The CORs were 5.44% and 4.91%. In Bland-Altman plot, most of the values were in 95% confidence interval. ICCs were 0.905[0.807, 0.955] and 0.912[0.818, 0.958].

Conclusions : The angle-independent hemodynamic parameters of retinal vessels from Doppler OCT system have good repeatability and reproducibility. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Fig 1. Measurement of reitnal blood flow. (a) En face view of optic disc area based on raster scan. (b) and (c) Four major arteries were obtaned based on repeated scan.

Fig 1. Measurement of reitnal blood flow. (a) En face view of optic disc area based on raster scan. (b) and (c) Four major arteries were obtaned based on repeated scan.

 

Fig2. Bland-Altman plots of hemodynamic parameters of inter-observer measurements and intra-observer measurement.

Fig2. Bland-Altman plots of hemodynamic parameters of inter-observer measurements and intra-observer measurement.

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