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Shenghai Huang, Meixiao Shen, Dexi Zhu, Ce Shi, Fan Lu; Repeatability and reproducibility of retinal hemodynamic parameters by using Doppler OCT. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3105.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the repeatability and reproducibility of angle-independent hemodynamic parameters in young health subjects by using Doppler optical coherence tomography (OCT).
A custom built spectral domain OCT was used to image retinal vessels in optic disc area. The phase resolved Doppler OCT was developed to obtain the pulsatility of retinal vessels. Two angle-independent, pulsatility index (PI) and resistance index (RI), were defined based pulsatility of vessels. 7 left eyes of 7 healthy subjects were included. The raster scan was first performed to obtain the morphology of retinal vessels. Then repeated scan at the superior and inferior of the optic disc was performed to get the Doppler images. Three repeated measurements was performed. The first two measurements were collected by examiner 1 for repeatability study and the last measurement was collected by examiner 2 for reproducibility study. The intraclass correlation coefficient (ICC), coefficients of repeatability and reproducibility (COR) and Bland-Altman plot were analyzed to evaluate the reliability.
A total of 28 vessels from 7 left eyes were collected at optic disc area for Doppler imaging. The value of PI was 1.34±0.22. The p-values of T-test for the intra-observer repeatability and inter-observer reproducibility were 0.570 and 0.968. The CORs were 13.97% and13.18%. In Bland-Altman plot, most of the values were in 95% confidence interval. ICCs were 0.922[0.840, 0.963] and 0.923[0.840, 0.963]. The value of RI was 0.89±0.08. The p-values of T-test for the intra-observer repeatability and inter-observer reproducibility were 0.491 and 0.939. The CORs were 5.44% and 4.91%. In Bland-Altman plot, most of the values were in 95% confidence interval. ICCs were 0.905[0.807, 0.955] and 0.912[0.818, 0.958].
The angle-independent hemodynamic parameters of retinal vessels from Doppler OCT system have good repeatability and reproducibility. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Fig 1. Measurement of reitnal blood flow. (a) En face view of optic disc area based on raster scan. (b) and (c) Four major arteries were obtaned based on repeated scan.
Fig2. Bland-Altman plots of hemodynamic parameters of inter-observer measurements and intra-observer measurement.
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