June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinotopic Imaging of Retinal and Cortical Structure and Function: A New Paradigm for Assessing the Visual Connectome in Health and Disease
Author Affiliations & Notes
  • Jeiran Choupan
    University of Southern California, LOS ANGELES, California, United States
  • Vivek Patel
    University of Southern California, LOS ANGELES, California, United States
  • Chris Purington
    University of Southern California, LOS ANGELES, California, United States
  • Noelle R. Stiles
    University of Southern California, LOS ANGELES, California, United States
  • Nihong Chen
    University of Southern California, LOS ANGELES, California, United States
  • Jessica Ijams Wolfing Morgan
    University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Andrew S. Bock
    University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Kimberly Kinga Gokoffski
    University of Southern California, LOS ANGELES, California, United States
  • Junyan Wang
    University of Southern California, LOS ANGELES, California, United States
  • Meng Law
    University of Southern California, LOS ANGELES, California, United States
  • Amir H Kashani
    University of Southern California, LOS ANGELES, California, United States
  • Geoffrey K K. Aguirre
    University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • James D Weiland
    University of Southern California, LOS ANGELES, California, United States
  • Yonggang Shi
    University of Southern California, LOS ANGELES, California, United States
  • Bosco S. Tjan
    University of Southern California, LOS ANGELES, California, United States
  • Footnotes
    Commercial Relationships   Jeiran Choupan, None; Vivek Patel, None; Chris Purington, None; Noelle Stiles, None; Nihong Chen, None; Jessica Morgan, None; Andrew Bock, None; Kimberly Gokoffski, None; Junyan Wang, None; Meng Law, None; Amir Kashani, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (R); Geoffrey K Aguirre, None; James Weiland, None; Yonggang Shi, None; Bosco Tjan, None
  • Footnotes
    Support  NIH 5U01EY025864-02, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3108. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jeiran Choupan, Vivek Patel, Chris Purington, Noelle R. Stiles, Nihong Chen, Jessica Ijams Wolfing Morgan, Andrew S. Bock, Kimberly Kinga Gokoffski, Junyan Wang, Meng Law, Amir H Kashani, Geoffrey K K. Aguirre, James D Weiland, Yonggang Shi, Bosco S. Tjan; Retinotopic Imaging of Retinal and Cortical Structure and Function: A New Paradigm for Assessing the Visual Connectome in Health and Disease. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3108.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Vision loss can lead to structural and functional changes in the brain. Such changes can impose preconditions on the outcomes of sight-restoration treatments. Characterizing the fine-scale relationships between retinal pathology and neuroimaging data enables a detailed analysis of the interplay between vision loss, brain plasticity and vision restoration. Presenting brain imaging in a format familiar to ophthalmologists will help generate novel insights.

Methods : There is a one-to-one and topology-preserving mapping between points in the brain and points on the retina in each of the brain regions that are part of the central visual pathway. This retinotopic organization allows brain measurements to be displayed in the same coordinates as a fundus image. Retinotopic coordinates for cortical areas V1-V3 were determined by fitting a deformable template [1] to digital reconstruction of a patient’s cortex derived from T1w MRI data. The template-derived retinotopic coordinates in V1 were extended to the optic radiation, reconstructed from diffusion MRI data [2].

Results : We present two patients with unilateral hemifield loss, one due to a recent onset of Non-Arteritic Ischemic Optic Neuropathy (NAION) (1 month prior to imaging) and another due to maculopathy caused by trauma (9 yr prior). Subjects underwent multimodal retinal and brain imaging. Functional assessments with microperimetry and fMRI (on-off full-field flashing light) were obtained. fMRI data were displayed in fundus coordinates. There was a striking qualitative correspondence between regions of fMRI signal modulation, retinal pathology and microperimetric field size. The spatial extent of attenuated V1 response often extended beyond the visible extent of the structural retinal lesion. The patient with a longer history of visual field loss showed a robust suppressive response in the V1 lesion projection zone. Cortical thickness in V1 did not reliably correlate with visual-field loss.

Conclusions : Projecting brain-imaging data to the coordinates of a fundus image enables direct comparisons between retinal structure and function and their impact on the central visual pathways. This novel visualization of brain imaging data is intuitive to ophthalmologists, leading to insights that are otherwise not readily available.
1. Benson NC, et al, PLoS Comput. Biol. 2014
2. Kammen A, et al, NeuroImage 2016
In honor and memory of Bosco S. Tjan, without whom this work would not have been possible

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×