June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Swept-source optical coherence tomography-based analysis of age-related changes in the peripheral retinal nerve fiber layer thickness
Author Affiliations & Notes
  • Gozde Hondur
    Ophthalmology, Columbia University, New York, New York, United States
    Glaucoma Service, Ulucanlar Ophthalmic Research and Training Hospital , Ankara, Turkey
  • Emre Goktas
    Ophthalmology, Columbia University, New York, New York, United States
  • Lama Al-Aswad
    Ophthalmology, Columbia University, New York, New York, United States
  • Gulgun Tezel
    Ophthalmology, Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Gozde Hondur, None; Emre Goktas, None; Lama Al-Aswad, None; Gulgun Tezel, None
  • Footnotes
    Support  RPB
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3996. doi:
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      Gozde Hondur, Emre Goktas, Lama Al-Aswad, Gulgun Tezel; Swept-source optical coherence tomography-based analysis of age-related changes in the peripheral retinal nerve fiber layer thickness. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3996.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine age-related changes in the peripheral retinal nerve fiber layer thickness (RNFLT) using swept-source optical coherence tomography (SS-OCT).

Methods : Forty eyes of 40 healthy subjects were studied in three age groups, group 1 (20-40 years, n: 15 eyes) group 2 (41-60 years, n: 14 eyes), and group 3 (61 years or older, n: 11 eyes). Peripapillary RNFLT values were calculated for temporal and nasal quadrants. Besides the routine wide-angle OCT imaging, additional OCT images of the nasal periphery were obtained with a contralateral gaze. Montaging the nasal peripheral and wide angle en-face OCT images yielded the large-field peripheral RNFLT image, including at least 6 mm nasal and temporal to the optic disc, and at least 3 mm superior and inferior to the optic disc (Figure 1). The 6 mm peripheral and peripapillary RNFLT values were calculated with the Deep Range Imaging algorhythm (DRI-OCT-1) of the Topcon SS-OCT. The ratio of peripheral RNFLT-to-peripapillary RNFLT was also calculated for the two quadrants. Kruskal-Wallis One Way Analysis of Variance on Ranks was used for comparison of the RNFLT values between different age groups.

Results : We observed an age-related decrease in the peripheral-to-peripapillary RNFLT ratios (p= 0.007 and 0.027 for the nasal and temporal quadrants, respectively). The age-related decrease in nasal peripheral RNFLT (p< 0.001) was more prominent than that in the temporal peripheral RNFLT (p= 0.018).

Conclusions : Montaged composite images with SS-OCT may provide valuable data for peripheral RNFLT. The age-related changes in peripheral RNFLT seem to appear earlier than that in peripapillary RNFLT. SS-OCT-based analysis analysis of the nasal peripheral RNFLT may provide additional information to routine wide-angle RNFLT analysis, which provides data for temporal peripheral RNFLT. Similar analysis in patients with ocular hypertension and glaucoma should determine whether age-related changes in the peripheral RNFLT may affect regional susceptibility for glaucoma or its clinical detection.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure 1: Montaging the routine wide-angle OCT image and the nasal peripheral OCT image, which was obtained with a contralateral gaze, yielded the large-field peripheral RNFLT image, including at least 6 mm nasal and temporal to the optic disc, and at least 3 mm superior and inferior to the optic disc.

Figure 1: Montaging the routine wide-angle OCT image and the nasal peripheral OCT image, which was obtained with a contralateral gaze, yielded the large-field peripheral RNFLT image, including at least 6 mm nasal and temporal to the optic disc, and at least 3 mm superior and inferior to the optic disc.

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