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Juan Pablo Davila, David Sarraf, Mansour Rahimi; OCT ANGIOGRAPHY of type 1 neovascularization in amd WITH LONG-TERM FOLLOW UP ANALYSIS. Invest. Ophthalmol. Vis. Sci. 2017;58(8):400.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the optical coherence tomography angiography (OCTA) analysis of type 1 choroidal neovascularization (CNV) in age related macular degeneration (AMD) after at least one year of treatment with anti-vascular endothelial growth factor (VEGF) injection therapy.
This retrospective OCTA analysis recruited eyes with type 1 neovascularization and AMD that underwent baseline and follow up OCTA imaging for at least 1 year. The findings of qualitative and quantitative OCTA analysis were reviewed at baseline and at last follow up. Various microvascular morphological features of the type 1 lesion were studied and a measurement of the area and density of the type 1 lesion was performed and the findings between the baseline and follow up visits were compared.
Thirty one eyes (13 right and 18 left eyes) with complete one year follow up OCT-A scans were reviewed. Fifteen male and 16 female patients, mean age 83.52 years (66-97 years).Mean visual acuity (VA) at month 0 was 0.51 LogMAR (20/64 Snellen). Previous anti-VEGF treatment, 6.3 aflibercept injections (24 eyes) and 13.64 ranibizumab injections (14 eyes).Mean area of type 1 CNV at baseline was 5.384mm2 (0.2829-35.75mm2) compared to 5.921mm2 (0.381-35.76mm2) at 12 months. We observe increase of the CNV area in 22 eyes (p<0.001 / SD 1.128), mean increase area 1.315mm2. Nine patients had decreased of the CNV area after one year (p=0.0426 / SD 2.083), mean decrease area -1.363mm2. Mean VA had no change 0.48LogMAR (20/60 Snellen). The average treatment during the one year follow up was 3.46 aflibercept and 1.5 ranibizumab injections respectively.
Quantitative analyses can be performed using OCT-A to follow the progression of type-1 choroidal membranes. Despite the anti-VEGF therapy type-1 CNV in AMD tend to increase in area throughout time even though visual acuity remains stable.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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