June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Quantification and functional correlations of macular microvasculature in the ganglion cell-inner plexiform layer in primary open angle glaucoma using OCT Angiography
Author Affiliations & Notes
  • Ingy Madi
    USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, United States
  • Arman Zaman
    USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, United States
  • Amir H Kashani
    USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, United States
  • Zhongdi Chu
    University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    University of Washington, Seattle, Washington, United States
  • Grace Marie Richter
    USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Ingy Madi, Carl Zeiss Meditech (F); Arman Zaman, Carl Zeiss Meditech (F); Amir Kashani, Carl Zeiss Meditech (F), Carl Zeiss Meditech (C), Carl Zeiss Meditech (R); Zhongdi Chu, None; Ruikang Wang, Carl Zeiss Meditech (F), Carl Zeiss Meditech (R), Carl Zeiss Meditech (C), Carl Zeiss Meditech (P); Grace Richter, Carl Zeiss Meditech (F)
  • Footnotes
    Support  unrestricted institutional grant from Research to Prevent Blindness (USC Roski Eye Institute),American Glaucoma Society Mentoring for Advancement of Physician Scientists (GMR),
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4263. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Ingy Madi, Arman Zaman, Amir H Kashani, Zhongdi Chu, Ruikang K Wang, Grace Marie Richter; Quantification and functional correlations of macular microvasculature in the ganglion cell-inner plexiform layer in primary open angle glaucoma using OCT Angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4263.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To quantify the microvasculature changes in the macula in primary open angle glaucoma (POAG) patients as measured from optical coherence tomography angiography (OCTA) en face images of the ganglion cell-inner plexiform layer; and to determine the strength of correlation of perfusion with hemifield mean deviation values.

Methods : 6x6 mm2 scans of the macula were obtained on POAG and normal patients using the Angioplex spectral-domain OCTA, and Humphrey Visual Field 24-2 mean deviation (MD) defects were calculated for superior and inferior hemifields in each eye using proprietary formulas (Carl Zeiss Meditech; Dublin, CA). Prototype software was used: (1) to perform semi-automatic segmentation of the raw OCTA data to obtain a precise ganglion cell-inner plexiform layer (GC-IPL) en face image, and (2) to calculate perfusion parameters including vessel area density (VAD), vessel skeleton density (VSD), and vessel complexity index (VCI) for the macula (globally, hemifields, and other focal sectors) (Figure 1). Perfusion parameters in normal and glaucomatous eyes were compared using Wilcoxon rank sum test. Strength of correlation between each perfusion parameter and the corresponding hemifield MD values were calculated using Spearman’s rank correlation.

Results : The study included 20 POAG eyes (12 mild/moderate [5 of which were preperimetric] and 8 severe) and 16 normal eyes. 6 eyes showed no visual field defects, 7 eyes had superior VF defects only, 2 eyes had inferior VF defects only, and 5 eyes had both. VAD, VSD, and VCI were significantly reduced with worsening severity of glaucoma (VAD P=0.0047; VCI P=0.0016; P= VSD 0.0023 using Kruskal-Wallis test). Glaucomatous eyes had significantly reduced perfusion parameters compared to normal eyes. There was a strong correlation between inferior HVF mean deviation and superior VAD (p= 0.0018), VSD (P= 0.000061), VCI (P= 0.000098) as well as globally (Figure 2).

Conclusions : Glaucomatous eyes with a range of no (preperimetric) to severe visual field defects showed significant reduction in macular perfusion parameters as compared to normal eyes. There was a strong correlation of degree of perfusion impairment with degree of corresponding visual field defects in hemifields. This method will likely prove useful in the future for diagnosis, staging and monitoring of glaucoma.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×