June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Morpho-functional relationship in children examined under anaesthesia for suspected retinal dystrophy and /or visual pathway alteration: a survey via indirect ophthalmoscopy with video camera, electroretinography and visual evoked potentials.
Author Affiliations & Notes
  • Giulio Ruberto
    Clinica Oculistica, IRCCS Policlinico San Matteo, Pavia, Italy
  • Rosanna Guagliano
    Clinica Oculistica, IRCCS Policlinico San Matteo, Pavia, Italy
  • Donatella Barillà
    Clinica Oculistica, IRCCS Policlinico San Matteo, Pavia, Italy
  • Margherita Bensi
    Clinica Oculistica, IRCCS Policlinico San Matteo, Pavia, Italy
  • Paolo Emilio Bianchi
    Clinica Oculistica, IRCCS Policlinico San Matteo, Pavia, Italy
  • Footnotes
    Commercial Relationships   Giulio Ruberto, None; Rosanna Guagliano, None; Donatella Barillà, None; Margherita Bensi, None; Paolo Bianchi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4672. doi:
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      Giulio Ruberto, Rosanna Guagliano, Donatella Barillà, Margherita Bensi, Paolo Emilio Bianchi; Morpho-functional relationship in children examined under anaesthesia for suspected retinal dystrophy and /or visual pathway alteration: a survey via indirect ophthalmoscopy with video camera, electroretinography and visual evoked potentials.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4672.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To correlate the fundus aspect recorded using a videocamera (Heine Omega 500 DV1) with the retinal response measured under anaesthesia via electroretinogram and the visual pathway examined in awake conditions by mean of visual evoked potentials (VEP).

Methods : We examined 17 children (mean age 18 months, min 9 months, max 8 years) that were referred to our clinic for visual impairment, visual unresponsiveness, nystagmus . After pupil dilatation, all the subjects had the fundus examined under anaesthesia and recorded on a PC with a high definition camera attached to an indirect ophthalmoscope. Electroretinogram (primus DB3, Lace electronics) was subsequently recorded using erg jet corneal electrodes. Before the anesthesia, children had patterned VEP elicited with a checker alternating on a screen (winaver, biomedical Mangoni) at different spatial frequencies (120’, 60’, 15’). The patients were divided in four groups: 1) normal ERG/VEP and fundus; 2) Normal ERG, altered VEP and abnormal fundus; 3) abnormal ERG/VEP, normal fundus; 4) abnormal ERG/VEP and fundus.

Results : In 5 children (29,41%) we found a normal ERG/VEP and fundus, 2 (11,76%) had normal ERG, and altered VEP and fundus, 4 (23,52%) altered ERG/VEP and normal fundus and 6 (35,29%, see figure 1) had ERG/VEP and fundus altered.

Conclusions : The functional ERG and Vep exams identify more (70,57%) retinal and visual pathway diseases than the funduscopy (47,05%), i.e. the functional alteration can be detected in advance compared to the morphologic alteration. Fundus examination performed using an indirect ophthtalmoscope equipped with a videocamera provides a good and relatively inexpensive retinal phenotype characterization.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

fundus picture in a 15-month-old child: a large macular dystrophy area is evident in a severe retinal dystrophy

fundus picture in a 15-month-old child: a large macular dystrophy area is evident in a severe retinal dystrophy

 

a highly reduced and delayed ERG is present in the same child of the previous figure

a highly reduced and delayed ERG is present in the same child of the previous figure

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