June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
OCT- Predictive Visual Threshold Sensitivity Predicts Visual Field Loss in Patients with Ocular Inflammatory Disease
Author Affiliations & Notes
  • James Jacobson Peairs
    Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa, United States
  • Michael David Abramoff
    Stephen A. Wynn Institute for Vision Research at the University of Iowa, Iowa City, Iowa, United States
    Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa, United States
  • Kyungmoo Lee
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
  • zhihui guo
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
  • Douglas B. Critser
    Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa, United States
  • James C Folk
    Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa, United States
  • Footnotes
    Commercial Relationships   James Peairs, None; Michael Abramoff, IDx LLC (I), IDx LLC (C), University of Iowa (P); Kyungmoo Lee, None; zhihui guo, None; Douglas Critser, None; James Folk, IDx LLC (I)
  • Footnotes
    Support  NIH Grants R01 EY019112, R01 EY018853; the Department of Veterans Affairs; Alimera Inc, The Robert C. Watzke MD Professorship for Retina Research
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 502. doi:
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    • Get Citation

      James Jacobson Peairs, Michael David Abramoff, Kyungmoo Lee, zhihui guo, Douglas B. Critser, James C Folk; OCT- Predictive Visual Threshold Sensitivity Predicts Visual Field Loss in Patients with Ocular Inflammatory Disease. Invest. Ophthalmol. Vis. Sci. 2017;58(8):502.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patients with ocular inflammatory disease often develop slowly progressive visual field loss. Visual fields, however, have inter-test variability and can be affected by media opacities and refractive errors. This study tested whether our automated OCT- Predictive Visual Threshold Sensitivity (OCT-PVST) can predict field loss compared to the Humphrey 24-2 (HVF 24-2).

Methods : 13 patients with idiopathic ocular inflammatory disease, confirmed by an uveitis expert and with known visual field defects on HVF 24-2 underwent pre-dilation Standard Humphrey 24-2 SITA perimetry. After dilation, our standard 9-field Spectralis OCT protocol was used, sequentially fixating on areas of retina 12.5° apart using a 3 × 3 grid pattern. This protocol entirely covers the 54° area tested with HVF. Using our automated pre-trained machine learning OCT-PVTS algorithm, which achieves 0.74 correlation with HVF 24-2 in patients with glaucoma, each 9-field OCT was co-registered and the nerve fiber, ganglion cell, and inner plexiform layers were co-segmented and each of the 52 HVF 24-2 testpoint thresholds was predicted and compared to HVF 24-2 measured thresholds.

Results : Average correlation between actual and predicted HVF 24-2 thresholds was 0.53. As demonstrated in figure 1, predicted visual field corresponded reasonably well in most subjects. In several cases, the actual HVF 24-2 was abnormal while the prediction was relatively normal (i.e. the neuroretina had normal thickness), although the outer retina did appear thinner (as demonstrated in figure 2).

Conclusions : Automated prediction of HVF 24-2 from 9-field OCT may have a role in management of patients with ocular inflammatory disease, if combined with analysis of the outer retina.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Left: actual field from HVF 24-2; center: predicted field from 9-field OCT; right: outer retinal layer thickness

Left: actual field from HVF 24-2; center: predicted field from 9-field OCT; right: outer retinal layer thickness

 

Left: actual field from HVF 24-2; center: predicted field from 9-field OCT; right: outer retinal layer thickness

Left: actual field from HVF 24-2; center: predicted field from 9-field OCT; right: outer retinal layer thickness

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