June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Compound Coherent Plane-Wave Ultrasound (CCPU) Imaging of Vascular Malformations in the Orbit
Author Affiliations & Notes
  • Ashley Campbell
    Ophthalmology , Columbia University Medical Center, New York, New York, United States
  • Alison Callahan
    Ophthalmology , Columbia University Medical Center, New York, New York, United States
  • Raksha Urs
    Ophthalmology , Columbia University Medical Center, New York, New York, United States
  • Ronald H Silverman
    Ophthalmology , Columbia University Medical Center, New York, New York, United States
  • Michael Kazim
    Ophthalmology , Columbia University Medical Center, New York, New York, United States
  • Footnotes
    Commercial Relationships   Ashley Campbell, None; Alison Callahan , None; Raksha Urs, None; Ronald Silverman, None; Michael Kazim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5144. doi:
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    • Get Citation

      Ashley Campbell, Alison Callahan, Raksha Urs, Ronald H Silverman, Michael Kazim; Compound Coherent Plane-Wave Ultrasound (CCPU) Imaging of Vascular Malformations in the Orbit. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5144.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : All prior color-flow Doppler ultrasound studies of the eye has been performed with non-commercial units that exceed U.S. Food and Drug Administration (FDA) permissible ultrasonic energy limits when applied to the eye. Our aim is to study normal vascular anatomy and vascular malformations in the orbit using a novel ultrafast compound coherent plane-wave ultrasound (CCPU) device to produce power Doppler images that complies with FDA guidelines.

Methods : Using a Versonics (Verasonics, Inc., Kirkland, WA) Vantage 128 ultrasound engine and a user-developed MATLAB (The MathWorks, Inc., Natick, MA) program with a 5 MHz linear-array probe, CCPU data were collected on patients with vascular malformations and normal orbits. Real-time color-flow Doppler visualized orbital blood flow. Power Doppler images were produced by post-processing CCPU images acquired continuously for 2-seconds.

Results : CCPU was performed on seven orbits (2 normal, 2 venolymphatic malformations, 1 arterio-venous malformation, 1 cavernous hemangioma, 1 orbital varix). The power Doppler images corresponding to MRI imaging from four of the cases are highlighted (Figures 1-4). Preliminary results demonstrate that CCPU produces higher-resolution depiction of orbital blood flow compared to conventional color-Doppler technology for normal vascular anatomy and orbital vascular malformations. There is also increased sensitivity to slow flow. In addition, CCPU produces much higher resolution of vascular malformations, dilated vessels and areas of abnormal blood flow when compared to standard MRI imaging.

Conclusions : CCPU is unfocused on emission; instead, focusing is performed on received echo data. Consequently, the ultrasound intensity is substantially lower than in conventionally focused ultrasound linear array systems and it falls well within FDA guidelines. CCPU offers a new modality to better understand normal ocular vascular anatomy and complex vascular malformations. Information regarding blood flow in orbital lesions is a valuable aid to treatment planning.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

24 year-old female with a biopsy proven right VLM debulked in 2006 now with regrowth.

24 year-old female with a biopsy proven right VLM debulked in 2006 now with regrowth.

 

37 year old female with infantile hemangioma with sudden onset of growth and associated hemorrhage at 26 weeks of her pregnancy.

37 year old female with infantile hemangioma with sudden onset of growth and associated hemorrhage at 26 weeks of her pregnancy.

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