June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correction of Perceived Visual Distortions Using a Software Application and Correlation to Age-Related Macular Degeneration.
Author Affiliations & Notes
  • Muhammad Hassan
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
  • Adithi Chakarvarthy
    University of Nebraska Omaha, Omaha, Nebraska, United States
  • Mahadevan Subramaniam
    University of Nebraska Omaha, Omaha, Nebraska, United States
  • Parvathi Chundi
    University of Nebraska Omaha, Omaha, Nebraska, United States
  • Muhammad Fayez Jawed
    Ophthalmology, University of Nebraska Medical Center , Omaha, Nebraska, United States
  • Muhammad Sohail Halim
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
  • Mohammad Ali Sadiq
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
  • Rubbia Afridi
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
  • Yasir Jamal Jamal Sepah
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Diana V Do
    Ophthalmology, Byers Eye Institute- Stanford University, Palo Alto, California, United States
    Ocular Imaging Research and Reading Center, Menlo Park, California, United States
  • Eyal Margalit
    Island Eye Surgery Specialists, Tamuning, Guam
  • Footnotes
    Commercial Relationships   Muhammad Hassan, None; Adithi Chakarvarthy, None; Mahadevan Subramaniam, None; Parvathi Chundi, None; Muhammad Fayez Jawed, None; Muhammad Halim, None; Mohammad Sadiq, None; Rubbia Afridi, None; Yasir Jamal Sepah, None; Quan Nguyen, None; Diana Do, None; Eyal Margalit, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5631. doi:
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      Muhammad Hassan, Adithi Chakarvarthy, Mahadevan Subramaniam, Parvathi Chundi, Muhammad Fayez Jawed, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Yasir Jamal Jamal Sepah, Quan Dong Nguyen, Diana V Do, Eyal Margalit; Correction of Perceived Visual Distortions Using a Software Application and Correlation to Age-Related Macular Degeneration.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5631.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effect of customized software-generated corrections in cancelling the perceived distortions in subjects with age-related macular degeneration (AMD).

Methods : An android tablet-based application displaying 3 lines (Fig. 1A) was utilized to elicit distortions. Five subjects (7 eyes: neovascular-AMD and 3 eyes: non-neovascular AMD) were asked to trace reference lines (RL) (Black line, Fig. 1A) and their distortion traces (DT) were recorded (green line, Fig. 1B). To counter the distortion, a compensatory software-generated trace (GT) was produced (purple line, Fig. 1B). The RL were recalibrated to GT and subject was asked to re-trace the lines. The corrected trace (CT) was recorded (yellow line, Fig. 1C) and compared to RL. Tablet recording was superimposed onto the en-face image of spectral domain optical coherence tomography (SD-OCT) (Fig. 1D). The number of distorted lines associated with an underlying lesion on SD-OCT was reported by two independent graders. To measure the effectiveness of correction, best fit lines were generated through the DT, GT and CT (Fig. 1E). The distortion and correction was measured by calculating the distance of DT(dDT) and CT(dCT) form the RL (Fig. 1F). Mean percentage improvement in the distortion was reported. Effectiveness of correction (EoC) was reported by utilizing t-test to compare the mean distance of DT and CT from RL (Fig. 1F).

Results : Mean age was 76.6 (±9.5) yrs. Each subject traced 6 RLs (3 Lines/eye). Each RL was treated as a separate case. We analyzed 30 cases: 17 (56.6%) cases elicited distortion while 13 cases without distortion were not analyzed further. Mean percentage improvement in distortion was 71.3±23.0%. There was a significant improvement in mean dCT compared to dGT (EoC; p<0.05). 12 cases (70.6%) had an AMD lesion associated with distortion; 8 cases with lesion had photoreceptor layer (PRL) disruption, while 4 had normal PRL. Mean EoC in cases with normal PRL was significantly higher than with abnormal PRL(P<0.05). 5 cases with distortion had no associated underlying lesion. Mean improvement in these subjects was significantly more than those with PRL disruption (p<0.05) and similar to those with normal PRL (p>0.05).

Conclusions : Software generated corrections can potentially correct for perceived distortions in subjects with AMD, especially in eyes with preserved photoreceptor layer.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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