June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Positive Correlation of High- and Low-Contrast ERG in Glaucoma Patients with Negative Correlation of High- and Low-Contrast VEP Latency
Author Affiliations & Notes
  • Rick Trevino
    Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, United States
  • William Eric Sponsel
    Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, United States
    Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, United States
  • Susan Ly Johnson
    Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, United States
  • Matthew Aaron Reilly
    Biomedical Engineering, Ohio State University, Columbus, Ohio, United States
  • Carolyn Majcher
    Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, United States
  • Footnotes
    Commercial Relationships   Rick Trevino, None; William Sponsel, Diopsys Inc. (C); Susan Johnson, None; Matthew Reilly, None; Carolyn Majcher, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5851. doi:
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      Rick Trevino, William Eric Sponsel, Susan Ly Johnson, Matthew Aaron Reilly, Carolyn Majcher; Positive Correlation of High- and Low-Contrast ERG in Glaucoma Patients with Negative Correlation of High- and Low-Contrast VEP Latency. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5851.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We have previously identified an inverse relationship between high contrast (Hc) and low contrast (Lc) visual evoked potential (VEP) latency in fellow eyes of certain glaucoma patients. The current study was undertaken to characterize electroretinogram (ERG) parameters in glaucoma patients displaying an inverse VEP latency relationship.

Methods : Clinical records of 440 adult glaucoma patients and suspects who underwent Diopsys® NOVA-LX to measure VEP Hc & Lc latency were reviewed to identify individuals with one significant Hc or Lc latency defect in each eye as determined by the device's intrinsic software. Exclusion criteria included eyes with any other ocular disease, TBI, unexplained visual loss, demyelinating conditions and neuropathies. The records of 32 patients that met the inclusion criteria were reviewed to identify those patients with Diopsys NOVA contrast sensitivity ERG results available for analysis.

Results : 14 (10F, 4M) of 32 patients (44%) had ERG data available for analysis. Their mean age (54.6y) did not differ significantly from the 18 patients without ERG data (p=0.88). There was no statistically significant difference between Magnitude (Mag) or Magnitude-D (MagD) between right and left eyes under Hc or Lc stimulus conditions. Linear regression analysis revealed significant positive correlation between Hc and Lc Mag (P = 0.01, r2 = 0.22) and between Hc and Lc Mag-D (P = 0.0002, r2 = 0.41) (FIGURE, panels A and C). In addition, there was significant positive correlation between right and left eyes for Mag (P < 0.0001, r2 = 0.63) and MagD (P = 0.0001, r2 = 0.44) (FIGURE, panels B and D).

Conclusions : Patients demonstrating significant negative correlation between Hc and Lc VEP latency demonstrate significant positive correlation in Hc and Lc ERG Mag and MagD. These findings suggest that the observed inverse VEP correlations may originate at centers above the level of the retina.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure: Significant positive correlations existed between high- and low-contrast ERG magnitudes in individual eyes (A) and between eyes (B). Statistically significant positive correlations were also observed for magnitude-D in individual eyes (C) and between eyes (D).

Figure: Significant positive correlations existed between high- and low-contrast ERG magnitudes in individual eyes (A) and between eyes (B). Statistically significant positive correlations were also observed for magnitude-D in individual eyes (C) and between eyes (D).

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