June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correlation between visual outcomes and anti-vegf injection frequency in neovascular age-related macular degeneration (nAMD) in Observe and Plan Regimen
Author Affiliations & Notes
  • Charlotte Rohart
    ophthalmology, Clinique Beausoleil, Montpellier, France
  • Loic Granados
    ophthalmology, Clinique Beausoleil, Montpellier, France
  • Sophie Navarre
    ophthalmology, Clinique Beausoleil, Montpellier, France
  • Sandrine Allieu
    ophthalmology, Clinique Beausoleil, Montpellier, France
  • Footnotes
    Commercial Relationships   Charlotte Rohart, None; Loic Granados, None; Sophie Navarre, None; Sandrine Allieu, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 430. doi:
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      Charlotte Rohart, Loic Granados, Sophie Navarre, Sandrine Allieu; Correlation between visual outcomes and anti-vegf injection frequency in neovascular age-related macular degeneration (nAMD) in Observe and Plan Regimen. Invest. Ophthalmol. Vis. Sci. 2017;58(8):430.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare visual acuity and morphologic features according to anti-vegf injection frequency in real-life in Observe and Plan Regimen after at least two years treatment period.

Methods : This was a french monocentrique retrospective study that included 80 eyes with nAMD. For all eyes, a personalized treatment regimen considering the recurrence interval was planned.
Study eyes were divided into two groups according the intravitreal anti-vegf injection frequency. Forty eyes were included in the group 1 with high injection frequency (4 to 7 weeks), and 40 eyes were included in the group 2 with low injection frequency (8 to 12 weeks).
Best corrected visual acuity (BCVA) and morphologic features at baseline and at recurrence were collected for all patients in each group.

Results : Patients characteristics were similar for two groups. The follow up was 37 months in group 1 and 39 months in group 2.
There was a significant difference between initial BCVA and final BCVA in each group (p < 0.05). The initial BCVA and the final BCVA were better in group 1 with high injection frequency (p<0.05). The final BCVA was 76 letters (ETDRS) in group 1 and 69 letters (ETDRS) in group 2. Morphologic features at baseline and at recurrence were different between two groups with subretinal fluid presence in 90 % in group 1 versus 60 % in group 2. In group 1, eyes were divided and analyzed into 2 subgroups : eyes with persistant fluid (23 eyes) and eyes with recurrence fluid (17 eyes).

Conclusions : In nAMD with Observe and Plan regimen, eyes with high injection frequency had better visual outcomes but needed intravitreal injection more frequently. More than 50% of these eyes with high injection frequency were associated with persistant fluid.
In aggreement with others studies, subretinal fluid was associated with better visual acuity.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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