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Yuka Hasegawa, Tomohito Sato, Rina Kinoshita, Yutaka Sakurai, Kozo Harimoto, Masaru Takeuchi; Comparison of visual acuity improvement by vitrecotmy for vitreous opacity between infections and non-infectious uveitis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):514.
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To evaluate outcome of diagnostic or therapeutic vitrectomy for vitreous opacity (VO) by comparing of the best corrected visual acuity (BCVA) before and after surgery between infectious and non-infectious uveitis patients.
Retrospective, single-practice data analysis from a medical record system. Forty-one eyes of 31 patients, in which diagnostic or therapeutic vitrectomy was performed for VO between April 2012 and March 2015 in National Defense Medical College, were reviewed. Twelve eyes of 10 patients were infectious uveitis (males/females; 5/5, average age ± standard deviation; 71.8 ± 10.8 years old, primary top 3 diseases; endophthalmitis 5 eyes, cytomegalovirus retinitis 3 eyes, acute retinal necrosis 1 eye, ocular toxoplasmosis 1 eye), and 29 eyes of 21 patients were noninfectious uveitis (males/females; 3/18, average age; 64.0 ± 12.2 years old, primary top 3 diseases; sarcoidosis 9 eyes, primary central nervous system lymphoma 4 eyes, Behcet's disease 2 eyes). BCVA before surgery and at 1, 3, and 6 months after surgery were converted to logMAR, and improvement rate of logMAR were evaluated by the ratio of postoperative logMAR to preoperative logMAR at the individual time points.
LogMAR before surgery, and at 1, 3, and 6 months after surgery were 1.76 ± 1.17, 0.99 ± 1.00, 1.04 ± 1.19, and 1.14 ± 1.04 in eyes with infectious uveitis, and were 0.52 ± 0.48, 0.17 ± 0.24, 0.18 ± 0.32 and 0.13 ±0.25 in eyes with noninfectious uveitis, respectively. LogMAR in eyes with infectious uveitis was significantly higher than those of noninfectious uveitis at each investigated point. However, improvement rates at 1, 3, and 6 months were 0.77 ± 1.10, 0.72 ± 1.19, and 0.62 ± 1.08 in eyes with infectious uveitis, and were 0.35 ± 0.44, 0.34 ± 0.42 and 0.38 ± 0.44 in eyes with noninfectious uveitis. There was no significant difference in postoperative improvement rates of logMAR at any investigated points between eyes with infectious uveitis and those with noninfectious uveitis.
The present study demonstrates that improvement rate of visual acuity by diagnostic or therapeutic vitrectomy for VO by infections uveitis was not statistically different from those by noninfections uveitis, although pre- and postoperative visual acuity are worse in infectious uveitis than in noninfectious uveitis.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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