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Kouzo Harimoto, Takahiro Kuraishi, Manzo Taguchi, Takayuki Kanda, Masaru Takeuchi; Age-related variations in systemic and ocular features of sarcoidosis patients. Invest. Ophthalmol. Vis. Sci. 2017;58(8):555.
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Sarcoidosis is a multisystem disorder of unknown etiology, in which the organs involved are histologically characterized by non-caseating granulomas. Ophthalmic involvement occurs in 30–60% of patients with sarcoidosis, the eye is the primary affected organ in some cases. Ocular sarcoidosis is the most frequent uveitis in Japan, and the predilection ages are 2 peaks at younger and older ages. In this study, we compared the background, the frequency of anterior and posterior segment involvements, and laboratory investigations between younger and elder sarcoidosis patients with uveitis.
Medical data of 98 ocular sarcoidosis patients diagnosed according to international criteria proposed by the International Workshop of Ocular Sarcoidosis at National Defense medical College between April 1, 2010 and July 31, 2016 were retrospectively reviewed. The patients were classified into two groups, younger group ( 49 patients ; 25~64 y/o , 17 males and 32 females ) and elder group ( 49 patients ; 65 y/o over , 13 males and 36 females), by less than or more than 65-year-old, and visual acuity, intraocular pressure, the frequency of mutton-fat keratic precipitates (KP), peripheral anterior synechia (PAS), snow-ball vitreous opacity (VO), retinochorial exudative spots (RE), cystoid macular edema (CME), epi-retinal membrebe (EP), bilateral hilar lymphadenopathy (BHL), angiotensin-converting enzyme (ACE) higher than 29.5 IU/L, and negative inversion of tuberculin skin test, and retinal thickness at the fovea (RT) measured by spectral-domain optical coherence tomography .
There were no significant differences in visual acuity, intraocular pressure, the frequency of EP, and negative inversion of tuberculin skin test between two groups. RT was significantly higher in elder group ( 328.4±124.1 µm) than in younger group ( 280.1±104.4 µm). However, the frequency of KP, PAS, VO, RE, CME, BHL, and high ACE were more in younger group than in elder group with statistical significance.
It was indicated that the characteristic findings are fewer in ocular sarcoidosis patients older than 65-year-old compared with the younger patients.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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