June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography in Patients with Focal, Diffuse, and Sclerotic Glaucomatous Optic Discs
Author Affiliations & Notes
  • Amir Marvasti
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Andrew Camp
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Adeleh Yarmohammadi
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Akram Belghith
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Linda M Zangwill
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Felipe Medeiros
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Robert N Weinreb
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego , Hamilton Glaucoma Center, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Amir Marvasti, None; Andrew Camp, None; Adeleh Yarmohammadi, None; Akram Belghith, None; Linda Zangwill, Carl Zeiss Meditec (F), Heidelberg Engineering (F), National Eye Institute (F), Optovue Inc (F), Topcon Medical Systems (F); Felipe Medeiros, Alcon (F), Alcon (R), Allergan (C), Allergan (F), Allergan (R), Bausch & Lomb (F), Carl Zeiss (C), Carl Zeiss (F), Carl Zeiss (R), Heidelberg Engineering (F), Merck (F), National Eye Institute (R), Novartis (C), Reichert (F), Reichert (R), Sensimed (F), Topcon (F); Robert Weinreb, Aerie Pharmaceutical (C), Alcon (C), Allergan (C), Bausch & Lomb (C), Carl Zeiss (F), Eyenovia (C), Forsight Vision V Sensimed (C), Genentech (F), Heidelberg Engineering (F), Optovue (F), Quark (F), Topcon (F), Unity (C)
  • Footnotes
    Support  UCSD Vision research core grant (P30EY022589), Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 716. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Amir Marvasti, Andrew Camp, Adeleh Yarmohammadi, Akram Belghith, Linda M Zangwill, Felipe Medeiros, Robert N Weinreb; Optical Coherence Tomography Angiography in Patients with Focal, Diffuse, and Sclerotic Glaucomatous Optic Discs. Invest. Ophthalmol. Vis. Sci. 2017;58(8):716.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To examine peripapillary vessel density measurements in glaucoma eyes with focal, diffuse, and sclerotic glaucomatous damage.

Methods : The study included 143 eyes of 143 patients with repeatable visual field defect and glaucomatous optic neuropathy. All eyes underwent optic disc digital photography, standard automated perimetry (SAP), spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCT-A). Optic disc photographs were reviewed by 2 masked observers (AHM and AC) and classified into focal, diffuse, and sclerotic patterns of disc damage. If a disc didn’t fit into one of these categories, it was labeled “other” and excluded from further analysis. In cases of disagreement, a third masked observer (RNW) adjudicated. Peripapillary microvasculature was measured by OCT-A global and sectoral (6 sectors) vessel density as the percentage of area occupied by flowing vessels. To assess focal microvascular loss, the difference in OCT-A sectoral vessel density between the sector with the lowest measurement and the mean of the remaining 5 sectors was measured and compared between various disc phenotypes.

Results : Thirty-six (25.2%) eyes were classified into the focal, 50 (35.0%) into the diffuse, and 31 (21.7%) into the sclerotic group. 26 (18.2%) were judged as “other”. There was no statistically significant difference in the mean visual field mean deviation (VF MD) (P=0.4) and mean global retinal nerve fiber layer thickness (P=0.7) between the three groups. Peripapillary vessel density in eyes with sclerotic damage (mean 49.4%) was lower than in eyes with focal (mean 54.4%) and diffuse (mean 53.1%) optic disc damage (P=0.005). Eyes with focal damage had a larger sectoral microvascular vessel density difference between the sector with the lowest measurement and the remaining 5 sectors compared to the diffuse and sclerotic group (11.1%, vs. 9.5% and 9.8%, respectively), although this difference did not reach a statistical difference (p=0.292).

Conclusions : Eyes with sclerotic damage might have greater peripapillary circulatory abnormalities. OCT-A might enhance our understanding of the role of ocular vasculature in the pathophysiology of glaucoma.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×