June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Baseline macular thickness correlates more strongly with changes in retinal capillary blood flow in open angle glaucoma patients with diabetes mellitus after 4 years
Author Affiliations & Notes
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Nathaniel Kim
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tyler Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Adrienne Ng
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University, Indianapolis, Indiana, United States
  • Yara Catoira-Boyle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Josh C Gross
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Alice Chandra Verticchio Vercellin, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Brent Siesky, None; Nathaniel Kim, None; Tyler Knight, None; Adrienne Ng, None; George Eckert, None; Yara Catoira-Boyle, None; Josh Gross, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY, American Diabetics Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 741. doi:
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    • Get Citation

      Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, Nathaniel Kim, Tyler Knight, Adrienne Ng, George Eckert, Yara Catoira-Boyle, Josh C Gross; Baseline macular thickness correlates more strongly with changes in retinal capillary blood flow in open angle glaucoma patients with diabetes mellitus after 4 years. Invest. Ophthalmol. Vis. Sci. 2017;58(8):741.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between baseline macular thickness and changes in retinal capillary blood flow in open angle glaucoma (OAG) patients with and without diabetes mellitus (DM) over 4 years.

Methods : 82 patients with OAG (16 with DM, 66 without DM) were evaluated for baseline macular thickness by optical coherence tomography and retinal capillary blood flow by Heidelberg retinal flowmetry (HRF) every 6 months for 4 years. Pearson correlations were used to test for associations between measurements with p<0.05 considered statistically significant.

Results : In OAG patients with DM, baseline outer nasal macular thickness (r=-0.64, p<0.01), inner nasal macular thickness (r=-0.77, p<0.00), outer temporal macular thickness (r=-0.53, p<0.04), and inner temporal macular thickness (r=-0.77, p<0.00) were negatively and significantly correlated with changes in the percentage of avascular area in the superior retina. In non-DM patients, these relationships were weakly correlated and significantly different compared to OAG patients with DM (all comparisons p<0.05). The percentage of avascular area in the inferior retina did not differ significantly between groups.

Conclusions : In OAG patients with DM, lower baseline macular thickness was associated with decreasing retinal capillary blood flow after 4 years.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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