June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal capillary blood flow in open-angle glaucoma patients of African descent decreases more over time compared to patients of European descent
Author Affiliations & Notes
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Nathaniel Kim
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Ingrida Januleviciene
    Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Amelia Huang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • June Geng
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Yara Catoira-Boyle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Josh C Gross
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Brent Siesky, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), ScienceBased Health (C), Stemnion (C); Alice Chandra Verticchio Vercellin, None; Nathaniel Kim, None; Ingrida Januleviciene, Alcon (C), Alcon (R), Allergan (C), Allergan (R), Origmed (C), Origmed (R), Santen (C), Santen (R), Vittamed (C), Vittamed (R); Amelia Huang, None; June Geng, None; Yara Catoira-Boyle, None; Josh Gross, None
  • Footnotes
    Support  NIH Grant 1R21EY022101-01A1; Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 744. doi:
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    • Get Citation

      Brent A Siesky, Alon Harris, Alice Chandra Verticchio Vercellin, Nathaniel Kim, Ingrida Januleviciene, Amelia Huang, June Geng, Yara Catoira-Boyle, Josh C Gross; Retinal capillary blood flow in open-angle glaucoma patients of African descent decreases more over time compared to patients of European descent. Invest. Ophthalmol. Vis. Sci. 2017;58(8):744.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the changes in retinal capillary blood flow in open angle glaucoma (OAG) patients of African (AD) and European descent (ED) over 3, 4, and 5 years.

Methods : OAG patients of AD and ED were assessed every 6 months for 3 years (18 AD, 58 ED), 4 years (20 AD, 59 ED), and 5 years (7 AD, 23 ED) for retinal capillary blood flow using Heidelberg retinal flowmetry (HRF). Mixed-model ANCOVA was used to test for statistically significant changes at 3, 4, and 5-year follow-up, and to test the differences between groups.

Results : In OAG patients of AD, the percentage of avascular area in the inferior retina significantly increased by 3.30% at 3 years (95% CI=1.30%, 5.00%; p<0.00), 4.20% at 4 years (1.90%, 6.20%; p<0.00), and 4.20% at 5 years (1.30%, 6.60%, p<0.01). In OAG patients of ED, the percentage of avascular area in the inferior retina increased by 0.10% at 3 years (-1.30%, 1.40%; p=0.86), 1.30% at 4 years (-0.50%, 3.00%; p=0.14), and 0.80% at 5 years (-1.20%, 2.70%; p=0.41). These changes in ED patients were smaller and insignificant, leading to significant differences between groups (p=0.01 at 3 years; p=0.03 at 4 years; p=0.04 at 5 years). The percentage of avascular area in the superior retina did not differ significantly between groups.

Conclusions : In OAG patients of AD, retinal capillary blood flow significantly decreases more over time compared to OAG patients of ED.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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