June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Management of chronic anterior uveitis relapses: efficacy of oral vitamin D treatment.
Author Affiliations & Notes
  • Giulia Malaguarnera
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
    Department of Ophtalmology, University of Catania, Catania, Italy
  • Davide Scollo
    Department of Ophtalmology, University of Catania, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Agata Messina
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Rosario Foti
    Rheumatologic Unit, Catania University, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Elisa Visalli
    Rheumatologic Unit, Catania University, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Roberta Amato
    Department of Ophtalmology, University of Catania, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Angela Cantavenera
    Department of Ophtalmology, University of Catania, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Mario Toro
    Department of Ophtalmology, University of Catania, Catania, Italy
  • Miriam Gallo Afflitto
    Department of Ophtalmology, University of Catania, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Caterina Gagliano
    Department of Ophtalmology, University of Catania, Catania, Italy
    Rare Diseases Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Footnotes
    Commercial Relationships   Giulia Malaguarnera, None; Davide Scollo, None; Agata Messina, None; Rosario Foti, None; Elisa Visalli, None; Roberta Amato, None; Angela Cantavenera, None; Mario Toro, None; Miriam Gallo Afflitto, None; Caterina Gagliano, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1095. doi:
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      Giulia Malaguarnera, Davide Scollo, Agata Messina, Rosario Foti, Elisa Visalli, Roberta Amato, Angela Cantavenera, Mario Toro, Miriam Gallo Afflitto, Caterina Gagliano; Management of chronic anterior uveitis relapses: efficacy of oral vitamin D treatment.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1095.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The role of vitamin D in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases such as uveitis. This study investigated the effect of vitamin D supplementation in patients with chronic anterior uveitis relapses. The primary end point of our work was the evaluation of relapse frequency in all treated patients, before and after Vitamin D treatment.

Methods : A total of 35 patients (21 men and 14 woman) aged 31–65 years and with relapses uveitis were enrolled in the study. They were treated with oral vitamin D (50.000 I.U. every week). Serum 25-hydroxyvitamin D (25(OH)D) levels were measured. All patients completed a 12-month follow-up therapeutic period.

Results : After 12 months of therapy, no eyes showed relapses uveitis. There was also an improvement in symptoms and signs associated with relapses after Vitamin D treatment, including ocular pain, blurring of vision, pericorneal hyperemia and aqueous or vitreous cells, and flare in 42% of patients.No patients had further reduction in visual acuity, 35% showed stabilization, and 65% showed statistically significant improvement (P = 0.0001 by Student’s t-test and P = 0.0005 by Wilcoxon signed rank test).

Conclusions : Our study demonstrate the potential therapeutic role of Vitamin D and its efficacy in eye relapsing diseases.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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