June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes
Author Affiliations & Notes
  • Mayss Al-Sheikh
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Nopasak Phasukkijwatana
    Department of Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
    Ophthalmology, Mahidol University, Bangkok, Bangkok, Thailand
  • Rosa Dolz-Marco
    Ophthalmology, Vitreous Retina Macula Consultants of New York, New York, New York, United States
  • Nicholas A Iafe
    Department of Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • K Bailey Freund
    Ophthalmology, Vitreous Retina Macula Consultants of New York, New York, New York, United States
    Department of Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
  • David Sarraf
    Department of Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Mayss Al-Sheikh, None; Nopasak Phasukkijwatana, None; Rosa Dolz-Marco, Alcon,, Bayer, Heidelberg Engineering, Allergan, Novartis, Thea (F); Nicholas Iafe, None; K Bailey Freund, Genentech, Optos, Optovue, Heidelberg Engineering, and Bayer HealthCare (C); Srinivas Sadda, Optos, Carl Zeiss Meditec, Allergan, Genentech, Thrombogenics, Novartis, and Iconic (C), Optos, Carl Zeiss Meditec, Allergan and Genentech (F); David Sarraf, Allergan, Heidelberg, Regeneron, Genentech and OptoVue (F), Novartis and Optovue, Bayer and Genentech (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1104. doi:
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      Mayss Al-Sheikh, Nopasak Phasukkijwatana, Rosa Dolz-Marco, Nicholas A Iafe, K Bailey Freund, Srinivas R Sadda, David Sarraf; Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1104.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using quantitative optical coherence tomography angiography (OCTA) analysis.

Methods : 3x3 macular OCTA images were obtained using the RTVue XR Avanti with AngioVue. Quantitative measurements of the retinal capillary microvascular layers and the CC were obtained using en face projection images. Vessel density and fractal dimension of the superficial and deep retinal capillary plexus, and area and density of flow reduction in the CC were analyzed, quantified and compared to an age-matched control group.

Results : Fifty eyes of 28 patients (15 female, 13 male) with myopia and thirty-four eyes of 20 age-matched healthy individuals were included. The vessel density and the vessel branching complexity using fractal dimension of the retinal capillary microvasculature were significantly lower in myopic eyes (P<0.001 and P=0.001). The number of flow void areas in the CC was lower (112.04 vs 139.09, P=0.002) but the total and average size was significantly higher (3.706±0.259 vs 3.592±0.192, P=0.038) compared to the healthy control group. Average choroidal thickness was less in the myopic group versus the normal control cohort (123.538±73.477 vs 246.97±41.745, P<0.05) and significantly less in eyes with lacquer cracks (LC) compared with myopic eyes without LC formation (P=0.003). There was no correlation between choroidal thickness and quantitative parameters of the CC in the myopic eyes.

Conclusions : The density of the retinal capillary microvasculature is reduced and the area of flow deficit in the CC is increased in eyes with greater myopia. The relevance of microvascular alterations in the setting of myopia warrants further study.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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