June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra wide-field fluorescein angiography: a pilot study
Author Affiliations & Notes
  • Lea Querques
    Ospedale S. Raffaele, Milano, Milan, Italy
    G.B. Bietti Foundation-IRCCS, Rome, Italy
  • Maria Cristina Parravano
    G.B. Bietti Foundation-IRCCS, Rome, Italy
  • Riccardo Sacconi
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Alessandro Rabiolo
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Maria Vittoria Cicinelli
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Adriano Carnevali
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Luigi De Vitis
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Giorgia Albertini
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Francesco Bandello
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Giuseppe Querques
    Ospedale S. Raffaele, Milano, Milan, Italy
  • Footnotes
    Commercial Relationships   Lea Querques, None; Maria Cristina Parravano, None; Riccardo Sacconi, None; Alessandro Rabiolo, None; Maria Vittoria Cicinelli, None; Adriano Carnevali, None; Luigi De Vitis, None; Giorgia Albertini, None; Francesco Bandello, Alcon (C), Alimera Sciences (C), Allergan Inc (C), Bausch And Lomb (C), Bayer Shering-Pharma (C), Farmila-Thea (C), Genentech (C), Hoffmann-La-Roche (C), NovagaliPharma (C), Novartis (C), Sanofi-Aventis (C), Thrombogenics (C), Zeiss (C); Giuseppe Querques, Alimera Sciences (C), Allergan Inc (C), Bayer Shering-Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2017, Vol.58, 923. doi:
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      Lea Querques, Maria Cristina Parravano, Riccardo Sacconi, Alessandro Rabiolo, Maria Vittoria Cicinelli, Adriano Carnevali, Luigi De Vitis, Giorgia Albertini, Francesco Bandello, Giuseppe Querques; Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra wide-field fluorescein angiography: a pilot study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):923.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effect dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME).

Methods : Patients with treatment naïve diabetic retinopathy undergoing intravitreal dexamethasone implant for diabetic macular edema (DME) between October 2015 and July 2016. Patients underwent a comprehensive ocular examination at baseline (< 2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best corrected visual acuity (BCVA), intraocular pressure (IOP), optical coherence tomography (OCT), ultra-widefield (UWF) retinography and UWF fluorescein angiography.

Results : Five eyes of three consecutive patients (all males; mean age 73.3 ± 10.1 years) with type 2 DM were enrolled. Mean duration of DR was 6.9 ± 3.9 years. Mean interval between UWFA acquisition was 12.1 ± 2.1 weeks and the mean interval between intravitreal injection and UWFA acquisition was 11.0 ± 1.6 weeks. Mean pre- and post-injection BCVA was 0.37 ± 0.21 logMAR and 0.29 ± 0.09 logMAR, respectively. Mean pre- and post-injection CMT was 457.8 ± 123.4 μm and 388.4 ± 50.3 μm, respectively. Mean pre- and post-injection ISI was 37.5 ± 26.2 % and 16.9 ± 12.2 % (2.2 folds reduction), respectively.

Conclusions : Intravitreal dexamethasone implant reduces peripheral retina ischemia in patients with DR.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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