June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Predicting 3-month response of DME to intravitreal conbercept from 24-hour response
Author Affiliations & Notes
  • Dawei Sun
    Ophthalmology, the 2nd affiliated hospital of Harbin Medical University, Harbin, Hei long jiang, China
  • Footnotes
    Commercial Relationships   Dawei Sun, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 929. doi:
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      Dawei Sun; Predicting 3-month response of DME to intravitreal conbercept from 24-hour response
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):929.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the clinical significant change in central foveal thickness (CFT) measured 24 hours after intravitreal injection conbercept (IVC) for diabetic macular edema (DME).
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Methods : Retrospective interventional case series. 23 eyes of 23 patients with DME who received monthly IVC (0.5 mg/0.05 mL) 3 times. CFT was measured using spectral-domain optical coherence tomography (sd-OCT) before injection, 24 hours and each month after injection until 3 months.
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Results : Statistically significant CFT reduction was observed at every key time points. Before injection as baseline, 24 hours after injection, 1,2 and 3 months after first injection. CFT declined from 587.5±125.8 µm at baseline to 423.7±117.9 µm 24 hours after first injection (p<0.01) and to 337.4±101.4 µm at 3 month after first injection (p<0.01). The reduction in CFT 24 hours after injection was significantly correlated with the reduction in CFT observed at 3 months after 3 injections, with respect to both absolute (r = 0.614, p = 0.008) and relative changes (r = 0.521, p = 0.019). The 13 eyes that had larger 24-hour CFT reductions also showed larger 3 month CFT reductions (187.5±76.7 µm and 31.8%±12.3%) when compared with 10 eyes with smaller 24 hours CFT reductions (96.8±51.5 µm and 16.5%±9.8%). This trend was the same for absolute and relative changes (p = 0.011 and 0.018).
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Conclusions : The 3 month response of DME to IVC can be predicted by checking CFT 24 hour after first injection.
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This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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