June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Agreement and Reproducibility of Tear Meniscus Parameters determined from Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Saumya Nagar
    DEI, DIRC, La Jolla, California, United States
  • Tudor Tepelus
    DEI, DIRC, La Jolla, California, United States
  • Elmira Baghdasaryan
    DEI, DIRC, La Jolla, California, United States
  • Ping Huang
    DEI, DIRC, La Jolla, California, United States
  • Ken Marion
    DEI, DIRC, La Jolla, California, United States
  • Susan S Lee
    Allergan, Irvine, California, United States
  • Olivia L Lee
    DEI, DIRC, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Saumya Nagar, Allergan (C); Tudor Tepelus, None; Elmira Baghdasaryan, None; Ping Huang, None; Ken Marion, None; Susan Lee, Allergan (E); Olivia Lee, Allergan (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1287. doi:
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      Saumya Nagar, Tudor Tepelus, Elmira Baghdasaryan, Ping Huang, Ken Marion, Susan S Lee, Olivia L Lee; Agreement and Reproducibility of Tear Meniscus Parameters determined from Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1287.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To measure and assess the agreement and reproducibility of tear meniscus parameters from two Spectral Domain Optical Coherence Tomography (SD-OCT) instruments.

Methods : The lower lid margin tear meniscus of 39 eyes from 20 healthy participants was imaged with both Spectralis (Heidelberg Engineering, Inc.) and Cirrus (Carl Zeiss Meditec, Inc) SD-OCTs. Tear meniscus height (TMH) and tear meniscus area (TMA) were measured using Image J. Inter-instrument and intra-instrument reproducibility of tear meniscus measurements were evaluated by intraclass correlation coefficients (ICCs). Inter-instrument agreement was evaluated with Bland-Altman analysis and determination of limits of agreement (LoA)

Results : The mean TMH was 0.275±0.063 mm using Cirrus and 0.263±0.899 mm using Spectralis. The mean TMA was 20.459±10.352 mm2 using Cirrus and 22.731±12.236 mm2 using Spectralis. Inter-instrument (ICCs>0.84) and intra-instrument (ICCs>0.91) reproducibility was good. Excellent agreement between the two devices was also observed with a mean difference of 0.012 (LoA: -0.073 to 0.0968) mm for TMH and -2.272 mm2 for TMA.

Conclusions : Both Spectralis and Cirrus tear meniscus images yielded comparable measurements for determination of tear meniscus parameters. Good inter- and intra-instrument reproducibility along with excellent agreement between both SD-OCT devices might allow interchangeability between the devices, potentially leading to the development of standardized tear meniscus grading methods across various SD-OCT devices.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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