June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The impact of lens opacification on SD-OCT retinal nerve fiber layer and Bruch’s membrane measurements using the Anatomical Positioning System
Author Affiliations & Notes
  • Matthias Marten Mauschitz
    Department for Population Sciences, German Center of Neurodegenerative Diseases, Bonn, Germany
  • Felix Roth
    Augenklinik Roth GmbH, Bonn, Germany
  • Frank G Holz
    Department for Ophthalmology, University of Bonn, Bonn, Germany
  • Monique M. B. Breteler
    Department for Population Sciences, German Center of Neurodegenerative Diseases, Bonn, Germany
  • Robert P. Finger
    Department for Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships   Matthias Marten Mauschitz, None; Felix Roth, None; Frank Holz, Acucela (F), Bayer Healthcare (F), Genentech (F), Heidelberg Engineering (F), Heidelberg Engineering (C), Novartis (F), Optos (F), Zeiss (F); Monique Breteler, None; Robert Finger, Abbvie (C), Abbvie (R), Bayer (C), Bayer (R), Novartis (C), Novartis (R), Santen (C), Santen (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1289. doi:
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      Matthias Marten Mauschitz, Felix Roth, Frank G Holz, Monique M. B. Breteler, Robert P. Finger; The impact of lens opacification on SD-OCT retinal nerve fiber layer and Bruch’s membrane measurements using the Anatomical Positioning System
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):1289.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Measurements of retinal layer thicknesses with Optical Coherence Tomography (OCT) are used increasingly often in clinical routine. Thus, assessments need to be as precise as possible. Lens opacification reportedly influences OCT derived retinal nerve fiber layer thickness (RNFLT) measurements. However, with recent improvements in OCT scanning and scan overlay at follow up, this might not hold true. Against this background the purpose of this study was to determine the influence of objectively determined lens opacification on SD-OCT measurements.

Methods : We enrolled 60 patients undergoing routine cataract surgery and assessed RNFLT and BMO parameters with SD-OCT (Spectralis, Heidelberg Engineering) one day before and one day after surgery. Accurate placement of the OCT scan at follow-up was performed using the Anatomic Positioning System (APS). This inbuilt device software recognizes individual anatomic landmarks and provides exact alignment at follow-up. Lens opacification was determined objectively with the Pentacam densitometry module using 25 Scheimpflug photographies (Pentacam AXL, Oculus GmbH).

Results : SD-OCT data was eligible in 59 (29 female) patients, mean age was 73±8.9 years. The mean differences in the RNFLT scans were 0µm (95% Confidence Interval -1.16; 1.16), -0.34µm (95% CI -1.30; 0.61) and -0.13µm (95% CI -1.22; 0.96) and none was statistically significant. The same was true for the differences in BMO and quality parameters. Average percentage of lens opacification was 13.14% (95% CI 12.56; 13.75).

Conclusions : Our data show no significant changes for any of the SD-OCT parameters. The percentage of lens opacification was comparable to that in similar studies. Our results challenge the previously described artificial alterations due to cataract. We hypothesize that the use of the APS prevented misplacement of the scans at follow-up. We conclude that cataract does not have a clinically relevant impact on SD-OCT RNFLT and BMO measurements using the APS.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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