June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Choroidal layer thickness in central serous retinopathy
Author Affiliations & Notes
  • Jay Chhablani
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Daren Hanumunthadu
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Elon HC van Dijk
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Sunila Dumpala
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Bindu Rajesh
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Ayesha Jabeen
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Asiya Jabeen
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Momin Ansari
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Pooja Mehta
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Shilpi Shah
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Chintan Sarvaiya
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Catherine Meyerele
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Lihteh Wu
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Alay Banker
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Giridhar Anantharaman
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Camiel JF Boon
    Vitreo-Retina, L V Prasad Eye Insititute, Hyderabad, India
  • Footnotes
    Commercial Relationships   Jay Chhablani, None; Daren Hanumunthadu, None; Elon HC van Dijk, None; Sunila Dumpala, None; Bindu Rajesh, None; Ayesha Jabeen, None; Asiya Jabeen, None; Momin Ansari, None; Pooja Mehta, None; Shilpi Shah, None; Chintan Sarvaiya, None; Catherine Meyerele, None; Lihteh Wu, None; Alay Banker, None; Giridhar Anantharaman, None; Camiel JF Boon, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1295. doi:
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      Jay Chhablani, Daren Hanumunthadu, Elon HC van Dijk, Sunila Dumpala, Bindu Rajesh, Ayesha Jabeen, Asiya Jabeen, Momin Ansari, Pooja Mehta, Shilpi Shah, Chintan Sarvaiya, Catherine Meyerele, Lihteh Wu, Alay Banker, Giridhar Anantharaman, Camiel JF Boon; Choroidal layer thickness in central serous retinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1295.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate medium (MCVT) and large (LCVT) choroidal vessel thickness in eyes with acute and chronic central serous retinopathy (CSR) in comparison with fellow eyes and age-matched controls.

Methods : Retrospective analysis of enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of patients with acute and chronic CSR and age-matched healthy subjects. Manual measurements of subfoveal choroidal thickness (SFCT), MCVT and LCVT at subfoveal and 750μm nasal and temporal to fovea locations were done by single observer using the ImageJ® software. One-way ANOVA with post hoc Tukey’s test was used for statistical analysis.

Results : 132 eyes of 96 subjects with CSR including 53 eyes with acute CSR, 43 with chronic CSR as well as and additional 36 fellow eyes. Mean age of CSR subjects was 45.5 (±8.5) years with 81 males. Thirty eyes of 30 age-matched subjects were included with mean age of 44.8 ± 9.4 years with 5 males. SFCT of acute CSR was significantly larger than fellow (p = 0.01) and normal eyes (p = 0.0001), but not eyes with chronic CSR. Subfoveal LCVT in acute CSR was more than normal eyes (p = 0.02). Subfoveal MCVT of acute CSR eyes was significantly more than fellow (p = 0.04) and control (p = 0.03) eyes, whilst mean thickness in eyes with chronic CSR was significantly more than control eyes (p = 0.04)

Conclusions : SFCT, MCVT and LCVT measurements are increased in eyes with acute CSR. However, thickening of medium choroidal vessels persists in chronic CSR. This is important in our understanding of disease activity in CSR, evaluation of chronicity of disease and development of structural end-points for clinical trials of treatments of CSR.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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