June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Evaluation of hyperreflective foci in diabetic macular edema by ultra-high resolution en face optical coherence tomography
Author Affiliations & Notes
  • Shintaro Nakao
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Yoshihiro Kaizu
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Iori Wada
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Muneo Yamaguchi
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Shigeo Yoshida
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Shin Tanaka
    Tokyo New Drug Research Laboratories, Kowa Company, Tokyo, Japan
  • Masaharu Mizuochi
    Tokyo New Drug Research Laboratories, Kowa Company, Tokyo, Japan
  • Tatsuro Ishibashi
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Koh-hei Sonoda
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Shintaro Nakao, Japanese Patent Application Number 2016-213815 (P); Yoshihiro Kaizu, None; Iori Wada, None; Muneo Yamaguchi, None; Shigeo Yoshida, None; Shin Tanaka, Japanese Patent Application Number 2016-213815 (P), Kowa Company, Ltd. (E); Masaharu Mizuochi, Kowa Company, Ltd. (E); Tatsuro Ishibashi, Japanese Patent Application Number 2016-213815 (P); Koh-hei Sonoda, Japanese Patent Application Number 2016-213815 (P)
  • Footnotes
    Support  JSPS KAKENHI (Tokyo, Japan), Grant-in-Aid for Young Scientists No. 25713057 and grants from Kowa Company, Ltd. (Tokyo, Japan).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1298. doi:
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      Shintaro Nakao, Yoshihiro Kaizu, Iori Wada, Muneo Yamaguchi, Shigeo Yoshida, Shin Tanaka, Masaharu Mizuochi, Tatsuro Ishibashi, Koh-hei Sonoda; Evaluation of hyperreflective foci in diabetic macular edema by ultra-high resolution en face optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1298.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Hyperreflective foci (HRF) is known to be observed in diabetic macular edema (DME) using optical coherence tomography. Various studies have shown the clinical relevance such as the association between HRF and visual acuity in DME patients. However, the analysis in previous studies could lack the quantitative properties because most researches used B scan to analyze HRF. In this study, we examined the utility of ultra-high resolution en face optical coherence tomography for detection of HRF in diabetic macular edema.

Methods : This prospective case series study evaluated 92 eyes of 46 consecutive cases with diabetes. All patients underwent a full ophthalmologic examination including ultra-high resolution spectral domain optical coherence tomography (Bi-µ: Kowa Company, Ltd, Nagoya, Japan). SD-OCT was performed using a 3X3mm raster scan pattern. HRF was quantified using a newly developed software.

Results : En face OCT images from 77 eyes of 43 cases (nine NDR, 29 NPDR without DME, 31 NPDR with DME) were analyzable to count the number of HRF. This method also could distinguish HRF from retinal vessels. The quantitative analysis showed 51.7±24.5, 84.5±45.4, 202.7±125.8 in NDR, NPDR without DME and NPDR without DME, respectively. The HRF number in NPDR without DME was significantly higher than one in NDR, whereas the eyes with DME showed significant more HRF compared with the eyes without DME in NPDR (p<0.01 and p<0.001, respectively).

Conclusions : Ultra-high resolution en face OCT could be useful to detect HRF in DME and the method might be clinical relevance in patients with DME.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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