June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Association between Visual Acuity and Retinal Layer Metrics in Diabetic Retinopathy by Enface OCT Imaging
Author Affiliations & Notes
  • Lakshmi Priya Ranagarju
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Michael Robert Tan
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Justin Wanek
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Norman P Blair
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Jennifer I Lim
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Mahnaz Shahidi
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Lakshmi Priya Ranagarju, None; Michael Tan, None; Justin Wanek, None; Norman Blair, None; Jennifer Lim, None; Mahnaz Shahidi, None
  • Footnotes
    Support  NIH grants DK104393, EY001792 and Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1299. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Lakshmi Priya Ranagarju, Michael Robert Tan, Justin Wanek, Norman P Blair, Jennifer I Lim, Mahnaz Shahidi; Association between Visual Acuity and Retinal Layer Metrics in Diabetic Retinopathy by Enface OCT Imaging. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1299.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Diabetic retinopathy (DR) causes alterations in retinal anatomy and progressive visual acuity (VA) loss. The relationship between increased central subfield thickness (CST) and reduced VA is well-established. The purpose of the current study is to identify alterations in individual retinal layer metrics of thickness, reflectance and interface disruption that are associated with reduced VA in DR by enface optical coherence tomography (OCT).

Methods : High density OCT volume scans were acquired in 115 diabetic subjects and best corrected VA (BCVA) was measured. Based on clinical diagnosis, the subjects were grouped as: no diabetic retinopathy (NDR; N=41), non-proliferative DR (NPDR; N=45) and proliferative DR (PDR; N=29; 23 of 29 had pan-retinal photocoagulation). An image segmentation method identified retinal layer interfaces and generated enface thickness maps and reflectance images of nerve fiber layer (NFL), ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL) and retinal pigment epithelium (RPE). Regions with disrupted layer interfaces were marked manually. Retinal layer metrics in the central subfield, including, thickness (CST, NFLT, GCLIPLT, INLT, OPLT, ONLT, OSLT, RPET), reflectance ratios relative to RPE (NFLR, GCLIPLR, INLR, OPLR, ONLR, OSLR) and disrupted interface areas relative to the total area (NFLd, INLd, ONLd, RPEd) were calculated.

Results : BCVA was significantly lower in both NPDR and PDR groups compared to NDR group (P<0.001). CST was significantly higher in NPDR group compared to NDR group (P=0.009) and marginally higher in PDR group compared to NDR group (P=0.06). Increased CST was associated with reduced BCVA (rs=-0.23, P=0.01), but the associations of reduced BCVA with increased INLT (rs=-0.44, P<0.001) and OPLT (rs=-0.28, P=0.002) were higher. Furthermore, reduced BCVA had a higher correlation with decreased OSLR (rs=0.34, P<0.001) than increased NFLR (rs=-0.23, P=0.02) and decreased OSLT (rs=0.23, P=0.01). Subjects with disrupted INL and ONL had lower BCVA as compared to subjects without disruptions (P=0.02).

Conclusions : Using enface OCT imaging, alterations in inner and outer retinal layer metrics were identified that may be useful for monitoring visual outcome due to progression and treatment of DR.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×