June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Macular drusen in Fuchs endothelial corneal dystrophy: a retrospective study using spectral-domain optical coherence tomography
Author Affiliations & Notes
  • Mario Matthaei
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Elena Elsner
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Albert Caramoy
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Werner Adler
    Department of Medical Informatics Biometry and Epidemiology, University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany
  • Sebastian E Siebelmann
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Friederike Schaub
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Yongwei Guo
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Bjoern Bachmann
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Claus Cursiefen
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Ludwig M Heindl
    Anterior Segment / Cornea, University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships   Mario Matthaei, None; Elena Elsner, None; Albert Caramoy, None; Werner Adler, None; Sebastian Siebelmann, None; Friederike Schaub, None; Yongwei Guo, None; Bjoern Bachmann, None; Claus Cursiefen, None; Ludwig Heindl, None
  • Footnotes
    Support  German Research Foundation (FOR 2240 "(Lymph)Angiogenesis And Cellular Immunity In Inflammatory Diseases Of The Eye" to CC and LMH; MA 5110/5-1 to MM; HE 6743/2-1 and HE 6743/3-1 to LMH; CU 47/6-1, CU 47/9- 1, CU 47/12-1 to CC), FORTUNE Program University of Cologne (to MM and to LMH); GEROK Program University of Cologne (to LMH), EU COST BM1302 "Joining Forces in Corneal Regeneration" (to CC), and Dr. Gabriele Lederle Foundation, Taufkirchen (to LMH).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1441. doi:
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    • Get Citation

      Mario Matthaei, Elena Elsner, Albert Caramoy, Werner Adler, Sebastian E Siebelmann, Friederike Schaub, Yongwei Guo, Bjoern Bachmann, Claus Cursiefen, Ludwig M Heindl; Macular drusen in Fuchs endothelial corneal dystrophy: a retrospective study using spectral-domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1441.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Putative pathogenic parallels have been suggested between guttae in Fuchs endothelial corneal dystrophy (FECD) and drusen in dry age-related macular degeneration. Hallmarks of both pathologies may include cellular degeneration accompanied by deposition and accumulation of extracellular matrix of the basal membrane both preferentially located within the central ocular lightpath. The present preliminary study aimed to find first evidence regarding a potenially increased incidence of macular drusen in FECD eyes compared to normal controls using spectral-domain optical coherence tomography (SD-OCT).

Methods : Retrospective, nonrandomized, case series. Clinically diagnosed FECD patients undergoing posterior lamellar keratoplasty at the Department of Ophthalmology, University of Cologne, Cologne, Germany were included. Patients without corneal pathologies served as controls. An evaluation of SD-OCT images was performed by independent investigators. Existence of drusen served as main outcome measure. Due to the dependency in the data structure, as both eyes per patient were examined, the effect of FECD, age, gender and previous cataract surgery on drusen was modelled with Generalized Estimating Equations (GEE).

Results : A total of n=221 consecutive FECD patients and n=235 normal corneal control patients were included in this study. Retrospective analysis of FECD images demonstrated, that presence of FECD and age had significant impact on the incidence of drusen of the macula with odds ratios of 1.643 (p=0.020) and 1.091 (p<0.001), respectively. Gender and previous cataract surgery did not show any corresponding impact.

Conclusions : Our data provides preliminary evidence that there may be a potential association between FECD and an increased incidence of drusen of the macula. However, these comparably early results will need further validation by future prospective studies in larger cohorts.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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