June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
LONG-TERM CUMULATIVE INCIDENCE OF AGE-RELATED MACULAR DENERATION IN LATINOS: THE LOS ANGELES LATINO EYE STUDY (LALES)
Author Affiliations & Notes
  • Farzana Choudhury
    Department of Ophthalmology, USC Eye Institute, University of Southern California, Los Angeles, California, United States
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Rohit Varma
    Department of Ophthalmology, USC Eye Institute, University of Southern California, Los Angeles, California, United States
  • Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Mina Torres
    Department of Ophthalmology, USC Eye Institute, University of Southern California, Los Angeles, California, United States
  • Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Farzana Choudhury, None; Rohit Varma, None; Ronald Klein, None; Mina Torres, None; Roberta McKean-Cowdin, None
  • Footnotes
    Support  NH Grant EY-11753, unrestricted Departmental grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1510. doi:
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      Farzana Choudhury, Rohit Varma, Ronald Klein, Mina Torres, Roberta McKean-Cowdin; LONG-TERM CUMULATIVE INCIDENCE OF AGE-RELATED MACULAR DENERATION IN LATINOS: THE LOS ANGELES LATINO EYE STUDY (LALES). Invest. Ophthalmol. Vis. Sci. 2017;58(8):1510.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To estimate the 8-year cumulative incidence of early and advanced age-related macular degeneration (AMD) in Latinos

Methods : Using standardized protocols, comprehensive ophthalmologic examinations were done including stereoscopic fundus photography on self-identified Latinos in Los Angeles, California at baseline (2000-2003) , at four-year follow-up (2004-2008) and at eight-year follow-up (2009-2013). Photographs were graded for specific AMD lesions using a modified Wisconsin Age-Related Maculopathy Grading System. For estimations of the 8-year incidence of AMD, the Age Related Eye Disease Study Scale was used. The main outcome measures were incidence of early AMD (drusen type, drusen size, and retinal pigmentary abnormalities) and advanced AMD (exudative AMD and geographic atrophy)

Results : The 8-year cumulative incidence of early AMD was 10.2% (95% CI: 6.1, 11.3) and advanced AMD was 0.6% (95% CI: 0.3, 0.9). There was an increasing trend of AMD cumulative incidence with increasing age at baseline (P<0.001). Higher incidence was observed in the second eye compared to the first eye for both early AMD [17.8 (95% CI: 14.8, 21.7%)] and late AMD [0.9 (95% CI: 0.1, 6.4%)]. Participants with large, indistinct soft drusen at baseline examination were more likely to develop advanced AMD lesions at the follow-up examination, compared to those who had hard or soft distinct drusen.
Annual age-adjusted average incidence of early and advanced AMD was 1.79% and 0.16% in this group of Latinos, compared to 1.36% (early AMD) and 0.23% (advanced AMD) in the non-Hispanic Whites of the Beaver-Dam Eye study.

Conclusions : Incidence of early AMD was slightly higher, and advanced AMD was lower, in Latinos of LALES than those reported in non-Hispanic whites. Compared to participants with other early AMD lesions, those with soft indistinct drusen at baseline had a higher risk of developing advanced AMD.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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