Purchase this article with an account.
Su Jeong Song, eun-jung rhee; High waist-hip ratio and increased risk of age related macular degeneration among Koreans. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1515.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Although there are many studies regarding obesity as a risk factor for age-related macular degeneration (AMD), the association between obesity and AMD is still controversial. This is maybe due to a fact that generalized obesity (as body mass index) cannot properly reflect the effect of obesity on human organs including retina. Recently, there are evidences that abdominal obesity (as waist-hip ratio) is more sensitive marker for accessing obesity than generalized obesity (as body mass index) on various disorders. So to analyze which parameter is better for accessing the effect of obesity on risk of AMD among Koreans, we compared body mass index and waist-hip ratio between subjects with AMD and without.
Seventy eight hundred and four subjects who participated in a health screening program at Kangbuk Samsung hospital during 2006 were included in this analysis. (Mean age 57 years, 57% men). To eliminate the effect of other disease that might affect the metabolic state of subjects, subjects with diabetes were excluded in this analysis. The presence of AMD was assessed by fundus photographs according to the international classification and grading system. The subjects were divided into two groups according to the presence and absence of AMD, and into four groups according to body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR).The linear trend analysis and multivariate logistic regression analyses were used for statistical analysis.
Among 7804 subjects, 218 subjects (2.8%) had AMD. The subjects with AMD were older, tend to be men, had higher mean WC and WHR and systolic blood pressure. The proportion of subjects with AMD did not show significant differences according to quartile groups of BMI or WC (p>0.05). However, the proportion of subjects with AMD significantly increased as WHR increased from 1st to 4th quartile group (1.5, 2.6, 3.2 and 3.8%, p for trend < 0.01).The risk for AMD was significantly increased in the 3rd quartile group compared to the 1st quartile group of WHR even after adjustment for confounding factors (odds ratio1.595, 95% confidence interval 1.000-2.543).
The subjects with AMD had high waist-hip ratio when compared with those with small waist-hip ratio. According to our study, the effect of waist-hip ratio was more pronounced than body mass index for accesssing obesity regarding risk of AMD among Koreans.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
This PDF is available to Subscribers Only