June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The Association Between Macula and Optic Nerve Head Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes
Author Affiliations & Notes
  • Patricia Isabel C Manalastas
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Linda M Zangwill
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Luke J Saunders
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Fabio Bernardi Daga
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Mark Christopher
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Adeleh Yarmohammadi
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Tadamichi Akagi
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Takuhei Shoji
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
  • Rafaella Cleto Penteado
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Min Hee Suh
    Ophthalmology, University of California, San Diego, San Diego, California, United States
    Ophthalmology, Haeundae Paik Hospital, Inje University, Busan, Korea (the Republic of)
  • Felipe Medeiros
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Robert N Weinreb
    Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Footnotes
    Commercial Relationships   Patricia Isabel Manalastas, None; Linda Zangwill, Carl Zeiss Meditec, Inc. (F), Heidelberg Engineering GmbH (F), National Eye Institute (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F); Luke Saunders, None; Fabio Daga, None; Mark Christopher, None; Adeleh Yarmohammadi, None; Tadamichi Akagi, Alcon (R), Kowa (R), Pfizer (R), Santen (R), Senju (R); Takuhei Shoji, Alcon (R), Kowa (R), Otsuka (R), Pfizer (R), Santen (R), Senju (R); Rafaella Penteado, None; Min Hee Suh, None; Felipe Medeiros, Alcon (F), Alcon (R), Allergan (C), Allergan (F), Allergan (R), Bausch & Lomb (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Heidelberg Engineering (F), Merck (F), National Eye institute (R), Novartis (C), Reichert (F), Reichert (R), Sensimed (F), Topcon (F); Robert Weinreb, Aerie Pharmaceuticals (C), Alcon (C), Allergan (C), Bausch & Lomb (C), Carl Zeiss Meditec (F), Evenovia (C), Forsight (C), Genentech (F), Heidelberg Engineering (F), Optos (F), Optovue (F), Sensimed (C), Topcon (F), Unity (C), VisionV (C)
  • Footnotes
    Support  UCSD Vision research core grant EY0222589; NIH Grants P30EY022589, EY11008, EY019869, EY021818, and participant retention incentive grants in the form of glaucoma medication at no cost from Alcon Laboratories Inc, Allergan, Pfizer Inc, and Santen Inc. Unrestricted grant from Research to Prevent Blindness, New York, New York.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1648. doi:
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    • Get Citation

      Patricia Isabel C Manalastas, Linda M Zangwill, Luke J Saunders, Fabio Bernardi Daga, Mark Christopher, Adeleh Yarmohammadi, Tadamichi Akagi, Takuhei Shoji, Rafaella Cleto Penteado, Min Hee Suh, Felipe Medeiros, Robert N Weinreb; The Association Between Macula and Optic Nerve Head Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1648.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCT-A) facilitates qualitative and quantitative assessment of the microvasculature of the eye. The diagnostic accuracy of optic nerve head (ONH) vessel density measurements has been shown to be similar to retinal nerve fiber layer (RNFL) thickness for discriminating between glaucoma and healthy eyes, but the relationship between macular vessel density and ONH vessel density has not yet been described. The purpose of this study was to evaluate the strength of the associations between ONH and macular OCT-A vessel density measurements with standard structural OCT measures.

Methods : This cross-sectional study included 335 eyes of 335 participants from the Diagnostics Innovations in Glaucoma Study (DIGS). This included 221 primary open angle glaucoma (POAG) patients, 40 glaucoma suspects, and 74 normal participants with good quality Optovue AngioVue images according to the Shiley Eye Institute Imaging Data Evaluation and Analysis (IDEA) Reading Center. The strength of the association between microvasculature measures in the ONH (whole image vessel density in the retinal nerve fiber layer (RNFL) and the macula (superficial layer) was assessed using linear regression models. Associations between ONH and macular vessel density, and RNFL thickness and ganglion cell complex (GCC) measures were also evaluated.

Results : All relationships between each variable were highly significant (p <0.001). A positive association was found between ONH whole image and macular vessel densities (R2 = 39.1%). This association was weaker than the relationship between GCC and RNFL thickness (R2 = 69.8%). Both RNFL and GCC thicknesses were more strongly associated with the ONH vessel density (R2 = 36.8% and 25.6%, respectively) than macular vessel density (R2 = 24.2% and 14.6%, respectively).

Conclusions : The strength and pattern of the association of ONH and macular microvasculature dropout and structural loss show promise for improving detection of glaucomatous progression.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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