June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Spatial pattern of retinal capillary dropout in diabetic retinopathy: evaluation using OCT angiography
Author Affiliations & Notes
  • Yoshihiro Kaizu
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Shintaro Nakao
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Takehito Hayami
    Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
  • Muneo Yamaguchi
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Iori Wada
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Kohta Fujiwara
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Shigeo Yoshida
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Tatsuro Ishibashi
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Koh-hei Sonoda
    Ophthalmology, Kyushu University, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Yoshihiro Kaizu, None; Shintaro Nakao, None; Takehito Hayami, None; Muneo Yamaguchi, None; Iori Wada, None; Kohta Fujiwara, None; Shigeo Yoshida, None; Tatsuro Ishibashi, None; Koh-hei Sonoda, None
  • Footnotes
    Support  JSPS KAKENHI (Tokyo, Japan), Grant-in-Aid for Young Scientists No. 25713057
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1661. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Yoshihiro Kaizu, Shintaro Nakao, Takehito Hayami, Muneo Yamaguchi, Iori Wada, Kohta Fujiwara, Shigeo Yoshida, Tatsuro Ishibashi, Koh-hei Sonoda; Spatial pattern of retinal capillary dropout in diabetic retinopathy: evaluation using OCT angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1661.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : It has been reported that foveal avascular zone (FAZ) could be enlarged during the progression of diabetic retinopathy. Our purpose in this study was to evaluate the retinal capillary dropout of macular area excepting FAZ enlargement in patients with diabetic retinopathy using optical coherence tomography angiography (OCTA).

Methods : This retrospective case control study included diabetic patients (18 NDR eyes, 19 NPDR eyes, 4 PDR eyes) and 28 healthy control subjects who underwent OCTA examination (RTVue XR Avanti: Optovue Inc, Fremont, California, USA). Retinal capillary densities of the whole 3x3 mm area as well as four divided areas (superior, inferior, lateral, nasal) excepting FAZ area were measured in 3x3 mm OCT angioflow images centered on the fovea using NI Vision Builder (National Instruments, Texas, USA).

Results : Retinal capillary densities of the whole 3x3 mm superficial OCTA images in healthy control, NDR, NPDR and PDR eyes were 45.6%, 39.7%, 37.7% and 34.2%, respectively. These of deep OCTA images were 59.7%, 51.6%, 42.8% and 34.2%, respectively. Retinal capillary densities of superficial as well as deep OCTA image in diabetic eye was significantly lower than these of healthy eyes (p<0.05, p<0.01, respectively). In superficial and deep OCTA images, there were no significant differences among the four areas (superior, inferior, lateral, nasal) in healthy, NDR, NPDR, and PDR eyes, respectively.

Conclusions : Retinal capillary dropout could be caused independently of FAZ enlargement and spatially evenly in the macular area of diabetic eyes.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×