June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical coherence tomography angiography analysis of the foveal avascular zone: evaluation and measurement of reproducibility and reliability in different settings.
Author Affiliations & Notes
  • Alessandro Arrigo
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Carlo La Spina
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Adriano Carnevali
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
    Department of Ophthalmology,, University of Magna Graecia, Catanzaro, Italy, Catanzaro, Italy
  • alessandro marchese
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Riccardo Sacconi
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Alessandro Rabiolo
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Lea Querques
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Maria Vittoria Cicinelli
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Giuseppe Querques
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Francesco Bandello
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Footnotes
    Commercial Relationships   Alessandro Arrigo, None; Carlo La Spina, None; Adriano Carnevali, None; alessandro marchese, None; Riccardo Sacconi, None; Alessandro Rabiolo, None; Lea Querques, None; Maria Vittoria Cicinelli, None; Giuseppe Querques, Alimera Sciences (C), Allergan Inc (C), Bayer Shering-Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C); Francesco Bandello, Alcon (C), Alimera Sciences (C), Allergan Inc (C), Bausch and Lomb (C), Bayer Shering-Pharma (C), Farmila-Thea (C), Genentech (C), Hoffmann-La Roche (C), NovagaliPharma (C), Novartis (C), Sanofi-Aventis (C), Thrombogenetics (C), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1672. doi:
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      Alessandro Arrigo, Carlo La Spina, Adriano Carnevali, alessandro marchese, Riccardo Sacconi, Alessandro Rabiolo, Lea Querques, Maria Vittoria Cicinelli, Giuseppe Querques, Francesco Bandello; Optical coherence tomography angiography analysis of the foveal avascular zone: evaluation and measurement of reproducibility and reliability in different settings.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1672.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The foveal avascular zone (FAZ) can be easily and non-invasively analyzed by means of optical coherence tomography angiography (OCTA). The main goal of present study is to assess reproducibility and reliability of FAZ evaluation by means of OCTA in different settings.

Methods : Twenty-four eyes of 24 normal subjects were investigated by using AngioVue OCTA Imaging System. Both basal and experimental settings following vasoactive stimuli OCTA acquisitions were taken. Images were evaluated separately by two operators and built-in automated tool were used to measure FAZ area.

Results : No differences for FAZ area were found in the repetition of basal acquisitions, neither in manual nor in automated measurement (0.215±0.06 VS 0.216±0.07, and 0.268±0.05 VS 0.264±0.09, first VS second basal measurement in square millimetres for manual and automated evaluation, p=0.25 and p=0.35, respectively). Inter-operators correlation was optimal (r2=0.978 [95% CI 0.981 to 0.976]). No differences were found among other settings, which included first basal and then repeated (second) in the morning, after flickering light stimulus, after Bruce treadmill stress test, after 30 minutes dark adaptation, and basal in the evening, neither in automated nor in manual measurements. Non-flow areas were found significantly larger using automated measurements if compared to the manual ones.

Conclusions : AngioVue OCTA Imaging System allows to obtain highly reproducible FAZ images with a high inter-operators concordance level. OCTA capability to detect FAZ area seems not to be influenced by any of the vasoactive stimuli considered in the current study. Moreover, automated measurement revealed larger non-flow areas than manual one.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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