June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography for Evaluation of the Fovea Avascular Zone in Diabetic Retinopathy
Author Affiliations & Notes
  • Yu-Qiang Soh
    Singapore National Eye Centre, Singapore, Singapore
  • Daniel Ting
    Singapore National Eye Centre, Singapore, Singapore
  • Tien Wong
    Singapore National Eye Centre, Singapore, Singapore
  • Ian Yeo
    Singapore National Eye Centre, Singapore, Singapore
  • Gemmy Chui Ming Cheung
    Singapore National Eye Centre, Singapore, Singapore
  • Gavin S Tan
    Singapore National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Yu-Qiang Soh, None; Daniel Ting, None; Tien Wong, None; Ian Yeo, None; Gemmy Cheung, None; Gavin Tan, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1673. doi:
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      Yu-Qiang Soh, Daniel Ting, Tien Wong, Ian Yeo, Gemmy Chui Ming Cheung, Gavin S Tan; Optical Coherence Tomography Angiography for Evaluation of the Fovea Avascular Zone in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1673.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Fundus fluorescein angiography (FFA) is currently the gold standard for the diagnosis of macular ischemia, a known complication of diabetic retinopathy (DR). Optical coherence tomography angiography (OCT-A) is a novel and non-invasive method for imaging of the retinal and choroidal vasculature. In contrast to FFA, OCT-A is able to differentiate between the retinal superficial vascular plexus (SVP) and deep vascular plexus (DVP). The purpose of this study is to evaluate the characteristics of foveal avascular zones (FAZ) captured by OCT-A, with reference to FFA, in patients with DR.

Methods : This is a prospective study involving 22 eyes (11 patients, 8 male) with varying DR severities (5 eyes had no DR; 6 had mild non-proliferative DR (NPDR); 6 had moderate NPDR; 2 had severe NPDR and 3 with proliferative DR). All eyes were imaged using OCT-A (Swept-Source Optical Coherence Tomography Angio™, Topcon Corp, Japan) and FFA (Spectralis® Scanning Laser Angiography, Heidelberg Engineering, Germany) to characterize their FAZ. We compared the FAZ area, maximum horizontal and vertical dimensions, for both superficial vascular plexus (SVP) and deep vascular plexus (DVP), between OCT-A and FFA.

Results : The mean age and HbA1C was 59.9 ± 11.6 years and 8.01 ± 1.65 % respectively. For OCT-A, measurements of FAZ area, horizontal and vertical dimensions were 0.335 ± 0.074 mm2, 0.656 ± 0.112 mm and 0.662 ± 0.087 mm at the SVP, and 0.277 ± 0.104 mm2, 0.605 ± 0.137 mm and 0.572 ± 0.142 mm at the DVP, respectively. The corresponding values obtained via FFA were 0.271 ± 0.135 mm2, 0.574 ± 0.140 mm and 0.561 ± 0.154 mm respectively. On OCTA, FAZ area was significantly larger in the SVP compared to DVP (p = 0.015). Comparing OCT-A to FFA , there were no statistically significantly differences in FAZ measurements comparing the SVP and FFA, mean area (p = 0.073), horizontal diameter (p = 0.1), vertical diameter (p = 0.551); or comparing DVP with FFA, mean area (p = 0.714), horizontal diameter (p = 0.956) and vertical diameter (p = 0.665).

Conclusions : OCT-A is comparable to FFA in regard to its ability to accurately characterize the FAZ. Further studies with larger sample sizes are required to confirm our findings.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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